A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold formed during wound healing, the type and composition of fibrin impacts the level of sprouting. More sprouts form on high molecular weight (HMW) than on low molecular weight (LMW) fibrin. It is unclear...

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Detalles Bibliográficos
Autores principales: Boas, Sonja E. M., Carvalho, Joao, van den Broek, Marloes, Weijers, Ester M., Goumans, Marie-José, Koolwijk, Pieter, Merks, Roeland M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072121/
https://www.ncbi.nlm.nih.gov/pubmed/29979675
http://dx.doi.org/10.1371/journal.pcbi.1006239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072121/
https://www.ncbi.nlm.nih.gov/pubmed/29979675
http://dx.doi.org/10.1371/journal.pcbi.1006239

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