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Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis

The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy cont...

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Autores principales: Wang, Zhe, Han, Yudi, Zhang, Zhaoqing, Jia, Cunfeng, Zhao, Qiang, Song, Wei, Chen, Tao, Zhang, Yifan, Wang, Xiuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072139/
https://www.ncbi.nlm.nih.gov/pubmed/29901120
http://dx.doi.org/10.3892/mmr.2018.9136
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author Wang, Zhe
Han, Yudi
Zhang, Zhaoqing
Jia, Cunfeng
Zhao, Qiang
Song, Wei
Chen, Tao
Zhang, Yifan
Wang, Xiuhui
author_facet Wang, Zhe
Han, Yudi
Zhang, Zhaoqing
Jia, Cunfeng
Zhao, Qiang
Song, Wei
Chen, Tao
Zhang, Yifan
Wang, Xiuhui
author_sort Wang, Zhe
collection PubMed
description The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed to identify differentially expressed genes (DEGs) associated with disease characteristics. Additionally, Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the DEGs were performed. Protein-protein, microRNA-transcription factor and chemical-gene interaction networks were constructed. A total of 326 DEGs, 196 upregulated and 130 downregulated, were identified. DEGs, including C-X-C motif chemokine ligand 5 (CXCL5), BCL2 interacting protein 3 like (BNIP3L), dual specificity phosphatase 5 (DUSP5) and tumor protein p53 (TP53) were enriched in functions associated with apoptosis, the cell cycle and immune responses. KEGG pathway enrichment analysis revealed that pathways associated with inflammation and the mitogen-activated protein kinase 1 (MAPK) signaling pathway were the most enriched by DEGs. The results of the present study indicated that the MAPK signaling pathway and four genes, including CXCL5, BNIP3L, DUSP5 and TP53, may be implicated in the pathogenesis of JSA.
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spelling pubmed-60721392018-08-06 Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis Wang, Zhe Han, Yudi Zhang, Zhaoqing Jia, Cunfeng Zhao, Qiang Song, Wei Chen, Tao Zhang, Yifan Wang, Xiuhui Mol Med Rep Articles The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed to identify differentially expressed genes (DEGs) associated with disease characteristics. Additionally, Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the DEGs were performed. Protein-protein, microRNA-transcription factor and chemical-gene interaction networks were constructed. A total of 326 DEGs, 196 upregulated and 130 downregulated, were identified. DEGs, including C-X-C motif chemokine ligand 5 (CXCL5), BCL2 interacting protein 3 like (BNIP3L), dual specificity phosphatase 5 (DUSP5) and tumor protein p53 (TP53) were enriched in functions associated with apoptosis, the cell cycle and immune responses. KEGG pathway enrichment analysis revealed that pathways associated with inflammation and the mitogen-activated protein kinase 1 (MAPK) signaling pathway were the most enriched by DEGs. The results of the present study indicated that the MAPK signaling pathway and four genes, including CXCL5, BNIP3L, DUSP5 and TP53, may be implicated in the pathogenesis of JSA. D.A. Spandidos 2018-08 2018-06-06 /pmc/articles/PMC6072139/ /pubmed/29901120 http://dx.doi.org/10.3892/mmr.2018.9136 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wang, Zhe
Han, Yudi
Zhang, Zhaoqing
Jia, Cunfeng
Zhao, Qiang
Song, Wei
Chen, Tao
Zhang, Yifan
Wang, Xiuhui
Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis
title Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis
title_full Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis
title_fullStr Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis
title_full_unstemmed Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis
title_short Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis
title_sort identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072139/
https://www.ncbi.nlm.nih.gov/pubmed/29901120
http://dx.doi.org/10.3892/mmr.2018.9136
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