A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor

We present herein a novel dissection-then-evolution strategy for ligand optimization. Using the co-crystal structure of the smoothened receptor (SMO) as a guide, we studied the modular contribution of LY2940680 by systematically “silencing” the specific interaction between the individual residue(s)...

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Detalles Bibliográficos
Autores principales: Ye, Lintao, Ding, Kang, Zhao, Fei, Liu, Xiaoyan, Wu, Yiran, Liu, Yang, Xue, Dongxiang, Zhou, Fang, Zhang, Xianjun, Stevens, Raymond C., Xu, Fei, Zhao, Suwen, Tao, Houchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072208/
https://www.ncbi.nlm.nih.gov/pubmed/30108845
http://dx.doi.org/10.1039/c7md00104e

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