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Novel bivalent securinine mimetics as topoisomerase I inhibitors

A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitor...

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Detalles Bibliográficos
Autores principales:	Hou, Wen, Lin, Hui, Wang, Zhen-Ya, Banwell, Martin G., Zeng, Ting, Sun, Ping-Hua, Lin, Jing, Chen, Wei-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072210/ https://www.ncbi.nlm.nih.gov/pubmed/30108747 http://dx.doi.org/10.1039/c6md00563b

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