Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family

Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae famil...

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Autores principales: Abdallah, Qasem, Al-Deeb, Ibrahim, Bader, Ammar, Hamam, Fayez, Saleh, Kamel, Abdulmajid, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072233/
https://www.ncbi.nlm.nih.gov/pubmed/29901194
http://dx.doi.org/10.3892/mmr.2018.9155
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author Abdallah, Qasem
Al-Deeb, Ibrahim
Bader, Ammar
Hamam, Fayez
Saleh, Kamel
Abdulmajid, Amin
author_facet Abdallah, Qasem
Al-Deeb, Ibrahim
Bader, Ammar
Hamam, Fayez
Saleh, Kamel
Abdulmajid, Amin
author_sort Abdallah, Qasem
collection PubMed
description Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae family were screened for their cytotoxic and anti-angiogenic activities using MTT and rat aortic ring assays, respectively. Four novel extracts of Thymbra capitata (L.) Cav., Phlomis viscosa Poir, Salvia samuelssonii Rech.f., and Premna resinosa (Hochst.) Schauer were identified for their selective anti-angiogenic effects. These extracts did not exhibit cytotoxic effects on human endothelial cells (EA.hy926) indicating the involvement of indirect anti-angiogenic mechanisms. The active extracts are potential candidates for further phytochemical and mechanistic studies.
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spelling pubmed-60722332018-08-06 Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family Abdallah, Qasem Al-Deeb, Ibrahim Bader, Ammar Hamam, Fayez Saleh, Kamel Abdulmajid, Amin Mol Med Rep Articles Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae family were screened for their cytotoxic and anti-angiogenic activities using MTT and rat aortic ring assays, respectively. Four novel extracts of Thymbra capitata (L.) Cav., Phlomis viscosa Poir, Salvia samuelssonii Rech.f., and Premna resinosa (Hochst.) Schauer were identified for their selective anti-angiogenic effects. These extracts did not exhibit cytotoxic effects on human endothelial cells (EA.hy926) indicating the involvement of indirect anti-angiogenic mechanisms. The active extracts are potential candidates for further phytochemical and mechanistic studies. D.A. Spandidos 2018-08 2018-06-12 /pmc/articles/PMC6072233/ /pubmed/29901194 http://dx.doi.org/10.3892/mmr.2018.9155 Text en Copyright: © Abdallah et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Abdallah, Qasem
Al-Deeb, Ibrahim
Bader, Ammar
Hamam, Fayez
Saleh, Kamel
Abdulmajid, Amin
Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family
title Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family
title_full Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family
title_fullStr Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family
title_full_unstemmed Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family
title_short Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family
title_sort anti-angiogenic activity of middle east medicinal plants of the lamiaceae family
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072233/
https://www.ncbi.nlm.nih.gov/pubmed/29901194
http://dx.doi.org/10.3892/mmr.2018.9155
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