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Enhanced Intercellular Delivery of cRGD–siRNA Conjugates by an Additional Oligospermine Modification
[Image: see text] Small interfering RNA (siRNA), consisting a 21-mer duplex molecule, is often modified by conjugation with specific ligands to enhance its capacity for tissue-specific delivery. However, these attempts are hampered by the low permeability of negatively charged RNA molecules to enter...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072241/ https://www.ncbi.nlm.nih.gov/pubmed/30087937 http://dx.doi.org/10.1021/acsomega.8b00850 |