Selection of a Water-Soluble Salt Form of a Preclinical Candidate, IIIM-290: Multiwell-Plate Salt Screening and Characterization

[Image: see text] IIIM-290, a semisynthetic derivative of natural product rohitukine, is an orally bioavailable Cdk inhibitor, efficacious in the xenograft models of colon, pancreatic, and leukemia cancer. Its low aqueous solubility (∼8.6 μg/mL) could be one of the reasons for achieving optimal in v...

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Detalles Bibliográficos
Autores principales: Kumar, Vikas, Bharate, Sandip B., Vishwakarma, Ram A., Bharate, Sonali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072253/
https://www.ncbi.nlm.nih.gov/pubmed/30087943
http://dx.doi.org/10.1021/acsomega.8b00801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072253/
https://www.ncbi.nlm.nih.gov/pubmed/30087943
http://dx.doi.org/10.1021/acsomega.8b00801

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