Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies

PURPOSE: The promise of precision oncology is that identification of genomic alterations will direct the rational use of molecularly targeted therapy. This approach is particularly applicable to neoplasms that are resistant to standard cytotoxic chemotherapy, like T-cell leukemias and lymphomas. In...

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Detalles Bibliográficos
Autores principales: Greenplate, Allison, Wang, Kai, Tripathi, Rati M., Palma, Norma, Ali, Siraj M., Stephens, Phil J., Miller, Vincent A., Shyr, Yu, Guo, Yan, Reddy, Nishitha M., Kozhaya, Lina, Unutmaz, Derya, Chen, Xueyan, Irish, Jonathan M., Davé, Utpal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2018
Materias:
Original Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072266/
https://www.ncbi.nlm.nih.gov/pubmed/30079384
http://dx.doi.org/10.1200/PO.17.00019

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