Cargando…

Osthole enhances antitumor activity and irradiation sensitivity of cervical cancer cells by suppressing ATM/NF-κB signaling

Osthole (7-methoxy-8-isopentenoxycoumarin) is an O-methylated coumarin, originally extracted from Chinese herbal medicine. It has been demonstrated that osthole has antitumor effects in various cancer cells in vitro. The present study assessed the effects of osthole on the regulation of cervical can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Che, Yilin, Li, Juan, Li, Zongjuan, Li, Jing, Wang, Shuai, Yan, Ying, Zou, Kun, Zou, Lijuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072300/ https://www.ncbi.nlm.nih.gov/pubmed/29989651 http://dx.doi.org/10.3892/or.2018.6514

Ejemplares similares

β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway
por: Yu, Xiaomu, et al.
Publicado: (2019)

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation
por: Jin, Yiyi, et al.
Publicado: (2018)

Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway
por: Liu, Kaili, et al.
Publicado: (2020)

Osthole protects sepsis-induced acute kidney injury via down-regulating NF-κB signal pathway
por: Yu, Chen, et al.
Publicado: (2016)

Osthole sensitizes with radiotherapy to suppress tumorigenesis of human nasopharyngeal carcinoma in vitro and in vivo
por: Peng, Lin, et al.
Publicado: (2018)

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial–mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway
por: Zou, Kun, et al.
Publicado: (2020)

Two Enhances the Cisplatin Sensitivity of Cervical Cancer Cells via Suppression of c-MET Expression
por: Chen, Ziqin, et al.
Publicado: (2023)

Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-κB in Normal Human Keratinocytes and Fibroblasts
por: Kordulewska, Natalia, et al.
Publicado: (2022)

Osthole Alleviates D-Galactose-Induced Liver Injury In Vivo via the TLR4/MAPK/NF-κB Pathways
por: Ma, Zhe, et al.
Publicado: (2023)

Targeting HMGB3/hTERT axis for radioresistance in cervical cancer
por: Li, Zongjuan, et al.
Publicado: (2020)

Osthole Sensitizes with Radiotherapy to Suppress Tumorigenesis of Human Nasopharyngeal Carcinoma in vitro and in vivo [Retraction]
Publicado: (2023)

Osthole Mitigates Progressive IgA Nephropathy by Inhibiting Reactive Oxygen Species Generation and NF-κB/NLRP3 Pathway
por: Hua, Kuo-Feng, et al.
Publicado: (2013)

Anti-Leishmania Activity of Osthole
por: Kermani, Elaheh Kordzadeh, et al.
Publicado: (2016)

Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway
por: Li, Ruyi, et al.
Publicado: (2021)

Sophocarpine Suppresses NF-κB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy
por: Zou, Fang, et al.
Publicado: (2019)

Mangiferin and Taurine Ameliorate MSRV Infection by Suppressing NF-κB Signaling
por: Dai, Caijiao, et al.
Publicado: (2023)

Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma
por: Zhu, Xingyang, et al.
Publicado: (2017)

ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα
por: Sinha, S, et al.
Publicado: (2013)

Osthole inhibits triple negative breast cancer cells by suppressing STAT3
por: Dai, Xuanxuan, et al.
Publicado: (2018)

Fluorescence spectroscopy of osthole binding to human serum albumin
por: Yang, Guang-De, et al.
Publicado: (2013)

Down-Regulation of EBV-LMP1 Radio-Sensitizes Nasal Pharyngeal Carcinoma Cells via NF-κB Regulated ATM Expression
por: Ma, Xiaoqian, et al.
Publicado: (2011)

Genistein Sensitizes Bladder Cancer Cells to HCPT Treatment In Vitro and In Vivo via ATM/NF-κB/IKK Pathway-Induced Apoptosis
por: Wang, Yong, et al.
Publicado: (2013)

Efficacy of Osthole in Management of Hypoperfused Retina
por: Du, Ran, et al.
Publicado: (2018)

β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways
por: Su, Pengyu, et al.
Publicado: (2020)

Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition
por: Zhang, Suping, et al.
Publicado: (2018)

Osthole-Mediated Inhibition of Neurotoxicity Induced by Ropivacaine via Amplification of the Cyclic Adenosine Monophosphate Signaling Pathway
por: Wang, WeiBing, et al.
Publicado: (2022)

TRIM10 Is Downregulated in Acute Myeloid Leukemia and Plays a Tumor Suppressive Role via Regulating NF-κB Pathway
por: Li, Lin, et al.
Publicado: (2023)

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
por: Zhao, Jing, et al.
Publicado: (2020)

The natural flavonoid glycoside vitexin displays preclinical antitumor activity by suppressing NF-κB signaling in nasopharyngeal carcinoma
por: Wang, Wenbin, et al.
Publicado: (2019)

Osthole Promotes Endochondral Ossification and Accelerates Fracture Healing in Mice
por: Zhang, Zhongrong, et al.
Publicado: (2016)

Osthole inhibits bone metastasis of breast cancer
por: Wu, Chunyu, et al.
Publicado: (2017)

The fluorescence of a mercury probe based on osthol
por: Luo, Guangyan, et al.
Publicado: (2021)

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer
por: Kim, Eunju, et al.
Publicado: (2022)

Osthole induces necroptosis via ROS overproduction in glioma cells
por: Huangfu, Mengjie, et al.
Publicado: (2021)

Osthole Induces Apoptosis and Inhibits Proliferation, Invasion, and Migration of Human Cervical Carcinoma HeLa Cells
por: Yin, Sugai, et al.
Publicado: (2021)

Osthole Antagonizes Microglial Activation in an NRF2-Dependent Manner
por: Liu, Chuan-Hsiu, et al.
Publicado: (2023)

Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway
por: Zhou, Xumin, et al.
Publicado: (2020)

Osthole decreases renal ischemia-reperfusion injury by suppressing JAK2/STAT3 signaling activation
por: Luo, Lin-Na, et al.
Publicado: (2016)

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway
por: Ma, Teng, et al.
Publicado: (2022)

The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro
por: Zhai, Yuan-Kun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ct9a8n43frcr1hhuh65uqvj0l8