Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor MK2206 in mammary cancer models

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Daily vs. weekly dosing with EGFR inhibitors (gefitinib and lapatinib) and an AKT inhibitor (MK2206) were compared in two rodent breast cancer models. Female Sprague-Dawley rats were administered methylnitrosourea (MNU) at 50 days of age, and gefitinib (daily/weekly dosing at 10/70 mg/kg BW) or lapa...

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Detalles Bibliográficos
Autores principales: Lubet, Ronald A., Steele, Vernon E., Juliana, M.M., Bode, Ann, Moeinpour, Fariba, Grubbs, Clinton J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072405/
https://www.ncbi.nlm.nih.gov/pubmed/29565450
http://dx.doi.org/10.3892/or.2018.6313
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