Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

We have examined the role of Fam60a, a gene highly expressed in embryonic stem cells, in mouse development. Fam60a interacts with components of the Sin3a-Hdac transcriptional corepressor complex, and most Fam60a(–/–) embryos manifest hypoplasia of visceral organs and die in utero. Fam60a is recruite...

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Detalles Bibliográficos
Autores principales: Nabeshima, Ryo, Nishimura, Osamu, Maeda, Takako, Shimizu, Natsumi, Ide, Takahiro, Yashiro, Kenta, Sakai, Yasuo, Meno, Chikara, Kadota, Mitsutaka, Shiratori, Hidetaka, Kuraku, Shigehiro, Hamada, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072441/
https://www.ncbi.nlm.nih.gov/pubmed/30070635
http://dx.doi.org/10.7554/eLife.36435

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