Dual gene activation and knockout screen reveals directional dependencies in genetic networks

Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins from Streptococcus pyogenes and Staphylococcu...

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Detalles Bibliográficos
Autores principales: Boettcher, Michael, Tian, Ruilin, Blau, James A., Markegard, Evan, Wagner, Ryan T., Wu, David, Mo, Xiulei, Biton, Anne, Zaitlen, Noah, Fu, Haian, McCormick, Frank, Kampmann, Martin, McManus, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072461/
https://www.ncbi.nlm.nih.gov/pubmed/29334369
http://dx.doi.org/10.1038/nbt.4062

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