Cargando…

53BP1/Rif1/Shieldin counteract DSB resection through CST/Polα-dependent fill-in

Resection of double-strand breaks (DSBs) dictates the choice between Homology-Directed Repair (HDR), which requires a 3′ overhang, and classical Non-Homologous End Joining (c-NHEJ), which can join unresected ends(1,2). BRCA1 mutant cancers show minimal DSB resection, rendering them HDR deficient and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mirman, Zachary, Lottersberger, Francisca, Takai, Hiroyuki, Kibe, Tatsuya, Gong, Yi, Takai, Kaori, Bianchi, Alessandro, Zimmermann, Michal, Durocher, Daniel, de Lange, Titia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072559/ https://www.ncbi.nlm.nih.gov/pubmed/30022158 http://dx.doi.org/10.1038/s41586-018-0324-7

Ejemplares similares

53BP1/shieldin-dependent DSB processing in BRCA1-deficient cells requires CST/Polα/primase fill-in synthesis
por: Mirman, Zachary, et al.
Publicado: (2022)

CST/Polα/primase-mediated fill-in synthesis at DSBs
por: Mirman, Zachary, et al.
Publicado: (2022)

Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action
por: Isobe, Shin-Ya, et al.
Publicado: (2021)

POT1 recruits and regulates CST–Polα/Primase at human telomeres
por: Cai, Sarah W., et al.
Publicado: (2023)

53BP1: a DSB escort
por: Mirman, Zachary, et al.
Publicado: (2020)

An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3–RIF1 interaction critical for shieldin activity
por: Sifri, Chérine, et al.
Publicado: (2023)

CST–Polα/Primase: the second telomere maintenance machine
por: Cai, Sarah W., et al.
Publicado: (2023)

The Shieldin complex mediates 53BP1-dependent DNA repair
por: Noordermeer, Sylvie M., et al.
Publicado: (2018)

Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state
por: Cai, Sarah W., et al.
Publicado: (2022)

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice
por: Batenburg, Nicole L., et al.
Publicado: (2017)

Rif1 Supports the Function of the CST Complex in Yeast Telomere Capping
por: Anbalagan, Savani, et al.
Publicado: (2011)

CST–Polymeraseα-primase solves a second telomere end-replication problem
por: Takai, Hiro, et al.
Publicado: (2023)

Disassembly of the Shieldin Complex by TRIP13
por: Sarangi, Prabha, et al.
Publicado: (2020)

Pol α-primase dependent nuclear localization of the mammalian CST complex
por: Kelich, Joseph M., et al.
Publicado: (2021)

DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres
por: Myler, Logan R., et al.
Publicado: (2023)

The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repair
por: Shimada, Kenji, et al.
Publicado: (2021)

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1
por: Bakr, Ali, et al.
Publicado: (2016)

Molecular basis for assembly of the shieldin complex and its implications for NHEJ
por: Liang, Ling, et al.
Publicado: (2020)

Shieldin complex assembly kinetics and DNA binding by SHLD3
por: Susvirkar, Vivek, et al.
Publicado: (2023)

Multifaceted regulation and functions of 53BP1 in NHEJ-mediated DSB repair (Review)
por: Lei, Tiantian, et al.
Publicado: (2022)

PHF11 promotes DSB resection, ATR signaling, and HR
por: Gong, Yi, et al.
Publicado: (2017)

Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex
por: Xie, Wei, et al.
Publicado: (2021)

Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
por: Schimmel, Joost, et al.
Publicado: (2021)

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
por: Dev, Harveer, et al.
Publicado: (2018)

MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
por: de Krijger, Inge, et al.
Publicado: (2021)

CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining
por: Iyer, Divya Ramalingam, et al.
Publicado: (2022)

The structure of the CstF-77 homodimer provides insights into CstF assembly
por: Legrand, Pierre, et al.
Publicado: (2007)

Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity
por: Davé, Anoushka, et al.
Publicado: (2014)

Interactions of CstF-64, CstF-77, and symplekin: Implications on localisation and function
por: Ruepp, Marc-David, et al.
Publicado: (2011)

Maintenance Cognitive Stimulation Therapy (CST) for dementia: A single-blind, multi-centre, randomized controlled trial of Maintenance CST vs. CST for dementia
por: Aguirre, Elisa, et al.
Publicado: (2010)

A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus
por: Takai, Hiroyuki, et al.
Publicado: (2016)

Mammalian Rif1 contributes to replication stress survival and homology-directed repair
por: Buonomo, Sara B.C., et al.
Publicado: (2009)

Protein disulfide bond generation in Escherichia coli DsbB–DsbA
por: Inaba, Kenji
Publicado: (2008)

Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens
por: Totsika, Makrina, et al.
Publicado: (2018)

Structure and function of the telomeric CST complex
por: Rice, Cory, et al.
Publicado: (2016)

The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity
por: Grozdanov, Petar N, et al.
Publicado: (2018)

Break-induced replication promotes fragile telomere formation
por: Yang, Zhe, et al.
Publicado: (2020)

Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3′ processing
por: Yao, Chengguo, et al.
Publicado: (2013)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2013)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l7ot7jjenei638pr5v5j4n902r