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Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations

A quantitative analysis of dose–response relationships is essential in preclinical and clinical drug development in order to optimize drug efficacy and safety, respectively. However, there is a lack of quantitative understanding about the dynamics of pharmacological drug–target interactions in biolo...

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Detalles Bibliográficos
Autores principales:	Thiel, Christoph, Smit, Ines, Baier, Vanessa, Cordes, Henrik, Fabry, Brigida, Blank, Lars Mathias, Kuepfer, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072773/ https://www.ncbi.nlm.nih.gov/pubmed/30083389 http://dx.doi.org/10.1038/s41540-018-0062-3

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