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Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients
This retrospective and a single-center study evaluated the prognostic value of the maximum serum creatinine value (maxCr) and the maximum serum creatinine growth rate (Vmax) after paraquat (PQ) ingestion. One hundred and seventy-one patients with PQ poisoning were treated with a uniform protocol. De...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072775/ https://www.ncbi.nlm.nih.gov/pubmed/30072769 http://dx.doi.org/10.1038/s41598-018-29800-0 |
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author | Feng, Meng-Xiao Li, Yu-Ning Ruan, Wei-Shuyi Lu, Yuan-Qiang |
author_facet | Feng, Meng-Xiao Li, Yu-Ning Ruan, Wei-Shuyi Lu, Yuan-Qiang |
author_sort | Feng, Meng-Xiao |
collection | PubMed |
description | This retrospective and a single-center study evaluated the prognostic value of the maximum serum creatinine value (maxCr) and the maximum serum creatinine growth rate (Vmax) after paraquat (PQ) ingestion. One hundred and seventy-one patients with PQ poisoning were treated with a uniform protocol. Demographic variables, clinical manifestations, relevant laboratory data, maxCr and Vmax of all patients were recorded and calculated. The time after PQ ingestion of maxCr and Vmax were also recorded. Vmax and MaxCr exhibited statistically significant differences between the survivor (n = 53) and death (n = 118) groups. Vmax appeared earlier in the death group than the survivor group. Regard to the receiver operating characteristic (ROC) curve analysis, Vmax had an AUC of 0.861 (95% CI, 0.801–0.921) and the optimal cut-off value of 6.21 μmol/(L·h) (sensitivity, 76.3%; specificity, 81.1%). MaxCr had an area under the curve (AUC) of 0.821 (95% CI, 0.752–0.889) and the optimal cut-off value of 225.5 µmol/L (sensitivity, 82.2%; specificity, 67.9%). The comparison of the AUC in the two parameters showed no significant difference, but Vmax appeared earlier than maxCr. Based on binary logistic regression analysis, MaxCr and Vmax both showed strong predictive powers for evaluating the prognosis of acute PQ poisoning patients. |
format | Online Article Text |
id | pubmed-6072775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60727752018-08-07 Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients Feng, Meng-Xiao Li, Yu-Ning Ruan, Wei-Shuyi Lu, Yuan-Qiang Sci Rep Article This retrospective and a single-center study evaluated the prognostic value of the maximum serum creatinine value (maxCr) and the maximum serum creatinine growth rate (Vmax) after paraquat (PQ) ingestion. One hundred and seventy-one patients with PQ poisoning were treated with a uniform protocol. Demographic variables, clinical manifestations, relevant laboratory data, maxCr and Vmax of all patients were recorded and calculated. The time after PQ ingestion of maxCr and Vmax were also recorded. Vmax and MaxCr exhibited statistically significant differences between the survivor (n = 53) and death (n = 118) groups. Vmax appeared earlier in the death group than the survivor group. Regard to the receiver operating characteristic (ROC) curve analysis, Vmax had an AUC of 0.861 (95% CI, 0.801–0.921) and the optimal cut-off value of 6.21 μmol/(L·h) (sensitivity, 76.3%; specificity, 81.1%). MaxCr had an area under the curve (AUC) of 0.821 (95% CI, 0.752–0.889) and the optimal cut-off value of 225.5 µmol/L (sensitivity, 82.2%; specificity, 67.9%). The comparison of the AUC in the two parameters showed no significant difference, but Vmax appeared earlier than maxCr. Based on binary logistic regression analysis, MaxCr and Vmax both showed strong predictive powers for evaluating the prognosis of acute PQ poisoning patients. Nature Publishing Group UK 2018-08-02 /pmc/articles/PMC6072775/ /pubmed/30072769 http://dx.doi.org/10.1038/s41598-018-29800-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Feng, Meng-Xiao Li, Yu-Ning Ruan, Wei-Shuyi Lu, Yuan-Qiang Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients |
title | Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients |
title_full | Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients |
title_fullStr | Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients |
title_full_unstemmed | Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients |
title_short | Predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients |
title_sort | predictive value of the maximum serum creatinine value and growth rate in acute paraquat poisoning patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072775/ https://www.ncbi.nlm.nih.gov/pubmed/30072769 http://dx.doi.org/10.1038/s41598-018-29800-0 |
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