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Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

To explore clinical characteristics which could be applied to predict pathologic complete response (pCR) for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (neo-CRT) and total mesorectal excision (TME). 297 patients with locally advanced rectal cancer (cT3-4...

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Autores principales: Peng, Haihua, Wang, Chengtao, Xiao, Weiwei, Lin, Xiaodan, You, Kaiyun, Dong, Jun, Wang, Zhenyu, Yu, Xiaobi, Zeng, Zhifan, Zhou, Tongchong, Gao, Yuanhong, Wen, Bixiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072814/
https://www.ncbi.nlm.nih.gov/pubmed/30087709
http://dx.doi.org/10.7150/jca.25493
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author Peng, Haihua
Wang, Chengtao
Xiao, Weiwei
Lin, Xiaodan
You, Kaiyun
Dong, Jun
Wang, Zhenyu
Yu, Xiaobi
Zeng, Zhifan
Zhou, Tongchong
Gao, Yuanhong
Wen, Bixiu
author_facet Peng, Haihua
Wang, Chengtao
Xiao, Weiwei
Lin, Xiaodan
You, Kaiyun
Dong, Jun
Wang, Zhenyu
Yu, Xiaobi
Zeng, Zhifan
Zhou, Tongchong
Gao, Yuanhong
Wen, Bixiu
author_sort Peng, Haihua
collection PubMed
description To explore clinical characteristics which could be applied to predict pathologic complete response (pCR) for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (neo-CRT) and total mesorectal excision (TME). 297 patients with locally advanced rectal cancer (cT3-4 or cN+) who were treated with neo-CRT followed by TME were retrospectively reviewed. Clinical characteristics including age, gender, tumor distance from anus, serum CEA, hemoglobin levels before treatment and clinical TN stage were used to investigate the association with pCR after neo-CRT. Seventy-nine (26.6%) patients achieved pCR after neo-CRT. pCR were achieved in 42 (34.4%) patients in cT1-3 stage and 37 (21.1%) in cT4 stage. pCR rate was 36.4% and 16.4% for patients with pre-treatment serum CEA ≤5.33ng/ml and >5.33ng/ml, respectively. Uni- and multi-variate analyses revealed that pre-treatment serum CEA level ≤5.33ng/ml and clinical T stage, (i.e., cT1-3 versus cT4) were highly correlated with pCR (p < 0.05). Clinical T stage and pre-treatment serum CEA level were strongly associated with pCR for patients with locally advanced rectal cancer treated with neo-CRT followed by TME which could be applied as clinical predictors for pCR.
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spelling pubmed-60728142018-08-07 Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy Peng, Haihua Wang, Chengtao Xiao, Weiwei Lin, Xiaodan You, Kaiyun Dong, Jun Wang, Zhenyu Yu, Xiaobi Zeng, Zhifan Zhou, Tongchong Gao, Yuanhong Wen, Bixiu J Cancer Research Paper To explore clinical characteristics which could be applied to predict pathologic complete response (pCR) for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (neo-CRT) and total mesorectal excision (TME). 297 patients with locally advanced rectal cancer (cT3-4 or cN+) who were treated with neo-CRT followed by TME were retrospectively reviewed. Clinical characteristics including age, gender, tumor distance from anus, serum CEA, hemoglobin levels before treatment and clinical TN stage were used to investigate the association with pCR after neo-CRT. Seventy-nine (26.6%) patients achieved pCR after neo-CRT. pCR were achieved in 42 (34.4%) patients in cT1-3 stage and 37 (21.1%) in cT4 stage. pCR rate was 36.4% and 16.4% for patients with pre-treatment serum CEA ≤5.33ng/ml and >5.33ng/ml, respectively. Uni- and multi-variate analyses revealed that pre-treatment serum CEA level ≤5.33ng/ml and clinical T stage, (i.e., cT1-3 versus cT4) were highly correlated with pCR (p < 0.05). Clinical T stage and pre-treatment serum CEA level were strongly associated with pCR for patients with locally advanced rectal cancer treated with neo-CRT followed by TME which could be applied as clinical predictors for pCR. Ivyspring International Publisher 2018-06-23 /pmc/articles/PMC6072814/ /pubmed/30087709 http://dx.doi.org/10.7150/jca.25493 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Peng, Haihua
Wang, Chengtao
Xiao, Weiwei
Lin, Xiaodan
You, Kaiyun
Dong, Jun
Wang, Zhenyu
Yu, Xiaobi
Zeng, Zhifan
Zhou, Tongchong
Gao, Yuanhong
Wen, Bixiu
Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
title Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
title_full Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
title_fullStr Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
title_full_unstemmed Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
title_short Analysis of Clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
title_sort analysis of clinical characteristics to predict pathologic complete response for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072814/
https://www.ncbi.nlm.nih.gov/pubmed/30087709
http://dx.doi.org/10.7150/jca.25493
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