β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor

BACKGROUND & AIMS: Knowledge about innate antimicrobial defense of the liver is limited. We investigated hepatic expression and regulation of antimicrobial peptides with focus on the human beta defensin-1 (hBD-1). METHODS: Radial diffusion assay was used to analyze antimicrobial activity of live...

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Detalles Bibliográficos
Autores principales: Klag, Thomas, Thomas, Maria, Ehmann, Dirk, Courth, Lioba, Mailänder-Sanchez, Daniela, Weiss, Thomas S., Dayoub, Rania, Abshagen, Kerstin, Vollmar, Brigitte, Thasler, Wolfgang E., Stange, Eduard F., Berg, Christoph P., Malek, Nisar P., Zanger, Ulrich M., Wehkamp, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072844/
https://www.ncbi.nlm.nih.gov/pubmed/30100908
http://dx.doi.org/10.3389/fimmu.2018.01735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072844/
https://www.ncbi.nlm.nih.gov/pubmed/30100908
http://dx.doi.org/10.3389/fimmu.2018.01735

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