Human Plasmablast Migration Toward CXCL12 Requires Glucose Oxidation by Enhanced Pyruvate Dehydrogenase Activity via AKT

Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of...

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Detalles Bibliográficos
Autores principales: Pak, Hyo-Kyung, Nam, Bora, Lee, Yoon Kyoung, Kim, Yong-Woo, Roh, Jin, Son, Jaekyoung, Chung, Yoo-Sam, Choe, Jongseon, Park, Chan-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072847/
https://www.ncbi.nlm.nih.gov/pubmed/30100910
http://dx.doi.org/10.3389/fimmu.2018.01742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072847/
https://www.ncbi.nlm.nih.gov/pubmed/30100910
http://dx.doi.org/10.3389/fimmu.2018.01742

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