Cargando…

Human Plasmablast Migration Toward CXCL12 Requires Glucose Oxidation by Enhanced Pyruvate Dehydrogenase Activity via AKT

Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pak, Hyo-Kyung, Nam, Bora, Lee, Yoon Kyoung, Kim, Yong-Woo, Roh, Jin, Son, Jaekyoung, Chung, Yoo-Sam, Choe, Jongseon, Park, Chan-Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072847/ https://www.ncbi.nlm.nih.gov/pubmed/30100910 http://dx.doi.org/10.3389/fimmu.2018.01742

Ejemplares similares

Regulator of G Protein Signaling 1 Suppresses CXCL12-Mediated Migration and AKT Activation in RPMI 8226 Human Plasmacytoma Cells and Plasmablasts
por: Pak, Hyo-Kyung, et al.
Publicado: (2015)

Escherichia coli Pyruvate Dehydrogenase Complex Is an Important Component of CXCL10-Mediated Antimicrobial Activity
por: Schutte, Kirsten M., et al.
Publicado: (2015)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

The Migration of Human Follicular Dendritic Cell-Like Cell Is Facilitated by Matrix Metalloproteinase 3 Expression That Is Mediated through TNFα-ERK1/2-AP1 Signaling
por: Pak, Hyo-Kyung, et al.
Publicado: (2021)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Effects of arsenic on pyruvate dehydrogenase activation.
por: Schiller, C M, et al.
Publicado: (1977)

Pyruvate dehydrogenase levels are low in sepsis
por: Nuzzo, E, et al.
Publicado: (2015)

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
por: Jeoung, Nam Ho, et al.
Publicado: (2010)

Metabolic rewiring of synthetic pyruvate dehydrogenase bypasses for acetone production in cyanobacteria
por: Lee, Hyun Jeong, et al.
Publicado: (2020)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Phenylbutyrate increases activity of pyruvate dehydrogenase complex
por: Ferriero, Rosa, et al.
Publicado: (2013)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Plasmablastic plasma cell myeloma mimicking plasmablastic lymphoma
por: Choi, Qute, et al.
Publicado: (2010)

Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure
por: Ferriero, Rosa, et al.
Publicado: (2018)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
por: Bedoyan, Jirair K., et al.
Publicado: (2019)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
por: Thibodeau, Alexa, et al.
Publicado: (2016)

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
por: Larrieu, Claire M., et al.
Publicado: (2022)

Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma
por: Dey, Prasanta, et al.
Publicado: (2019)

Escherichia coli aceE variants coding pyruvate dehydrogenase improve the generation of pyruvate‐derived acetoin
por: Moxley, W. Chris, et al.
Publicado: (2023)

Plasmablastic lymphoma in Malawi
por: Zuze, Takondwa, et al.
Publicado: (2018)

Orbital plasmablastic lymphoma
por: Bloch, Edward, et al.
Publicado: (2017)

Plasmablastic lymphoma: An update
por: Bailly, Jenique, et al.
Publicado: (2022)

Oral Tolerance and Pyruvate Dehydrogenase in Patients with Primary Biliary Cirrhosis
por: Suzuki, Ayako, et al.
Publicado: (2002)

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
por: Sutendra, Gopinath, et al.
Publicado: (2013)

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency
por: Rodrigues, Ana Sofia, et al.
Publicado: (2015)

Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
por: Rajagopalan, Kartik N., et al.
Publicado: (2015)

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy
por: Zeng, Zhenhua, et al.
Publicado: (2021)

Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency
por: Karissa, Patricia, et al.
Publicado: (2022)

Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency
por: Ogawa, Eri, et al.
Publicado: (2023)

The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation
por: Kolitsida, Panagiota, et al.
Publicado: (2023)

Plasmablastic Lymphoma or Plasmablastic Myeloma: A Case of Post-Transplant Lymphoproliferative Disorder
por: Ramadas, Poornima, et al.
Publicado: (2021)

Phosphorylated form of pyruvate dehydrogenase α1 mediates tumor necrosis factor α-induced glioma cell migration
por: Yang, Zijun, et al.
Publicado: (2021)

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
por: Lee, Sun Joo, et al.
Publicado: (2015)

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression
por: Meiser, Johannes, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ka0clnqa53q3re0lf23hj7q8sp