Cargando…

GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling

G protein-coupled receptors (GPCRs) are a large diverse family of cell surface signaling receptors implicated in various types of cancers. Several studies indicate that GPCRs control many aspects of cancer progression including tumor growth, invasion, migration, survival and metastasis. While it is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arakaki, Aleena K. S., Pan, Wen-An, Trejo, JoAnn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073120/ https://www.ncbi.nlm.nih.gov/pubmed/29954076 http://dx.doi.org/10.3390/ijms19071886

Ejemplares similares

Endocytic Adaptors in Cardiovascular Disease
por: Cui, Kui, et al.
Publicado: (2020)

Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling
por: Toruń, Anna, et al.
Publicado: (2015)

Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1
por: Wolfe, Breann L., et al.
Publicado: (2007)

Epsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer Progression
por: Tessneer, Kandice L., et al.
Publicado: (2013)

Endocytic Adaptor Protein Epsin Is Elevated in Prostate Cancer and Required for Cancer Progression
por: Tessneer, Kandice L., et al.
Publicado: (2013)

CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic
por: Wang, Yuxiao, et al.
Publicado: (2019)

The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines
por: Boczek, Tomasz, et al.
Publicado: (2021)

PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors
por: Budzinska, Marta I., et al.
Publicado: (2020)

Stonin 2: An Adaptor-like Protein That Interacts with Components of the Endocytic Machinery
por: Martina, José A., et al.
Publicado: (2001)

Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development
por: Yap, Chan Choo, et al.
Publicado: (2015)

Safeguards of Neurotransmission: Endocytic Adaptors as Regulators of Synaptic Vesicle Composition and Function
por: Kaempf, Natalie, et al.
Publicado: (2017)

The protein kinase Akt acts as a coat adaptor in endocytic recycling
por: Hsu, Jia-Wei, et al.
Publicado: (2020)

G Protein-Coupled Receptors (GPCRs)-Mediated Calcium Signaling in Ovarian Cancer: Focus on GPCRs activated by Neurotransmitters and Inflammation-Associated Molecules
por: Predescu, Dragoș-Valentin, et al.
Publicado: (2019)

HPV-16 E7 Interacts with the Endocytic Machinery via the AP2 Adaptor μ2 Subunit
por: Basukala, Om, et al.
Publicado: (2022)

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development
por: Ates, Kristin M., et al.
Publicado: (2020)

Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
por: Traub, Linton M.
Publicado: (2003)

The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers
por: Pozzi, Benedetta, et al.
Publicado: (2012)

Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2
por: Jung, Nadja, et al.
Publicado: (2007)

Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers
por: Pozzi, Benedetta, et al.
Publicado: (2013)

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations
por: Azarnia Tehran, Domenico, et al.
Publicado: (2019)

Editorial: GPCRs and Cancer
por: Chen, Suzie
Publicado: (2017)

UIM domain-dependent recruitment of the endocytic adaptor protein Eps15 to ubiquitin-enriched endosomes
por: Gucwa, Azad L, et al.
Publicado: (2014)

SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses
por: Lee, Sang-Eun, et al.
Publicado: (2019)

Transcriptomic Analysis of Extracellular RNA Governed by the Endocytic Adaptor Protein Cin1 of Cryptococcus deneoformans
por: Liu, Muxing, et al.
Publicado: (2020)

Lowe syndrome–linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum
por: Luscher, Alexandre, et al.
Publicado: (2019)

Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking of Epidermal Growth Factor Receptor in Neuronal Dendritic Development
por: Yang, Qian, et al.
Publicado: (2018)

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer
por: Liang, Weiwei, et al.
Publicado: (2020)

Specific functions of lysosomal proteases in endocytic and autophagic pathways()
por: Müller, Sabrina, et al.
Publicado: (2012)

Roles of G Protein-Coupled Receptors (GPCRs) in Gastrointestinal Cancers: Focus on Sphingosine 1-Shosphate Receptors, Angiotensin II Receptors, and Estrogen-Related GPCRs
por: Zeng, Zhen, et al.
Publicado: (2021)

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
por: Lizarrondo, Javier, et al.
Publicado: (2021)

The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
por: Laboute, Thibaut, et al.
Publicado: (2020)

G Protein-Coupled Receptors (GPCRs) in Alzheimer’s Disease: A Focus on BACE1 Related GPCRs
por: Zhao, Juan, et al.
Publicado: (2016)

GPCRs: The most promiscuous druggable receptor of the mankind
por: Alhosaini, Khaled, et al.
Publicado: (2021)

Enhancing the Signaling of GPCRs via Orthosteric Ions
por: Chan, H. C. Stephen, et al.
Publicado: (2020)

Endomembrane-Based Signaling by GPCRs and G-Proteins
por: Liccardo, Federica, et al.
Publicado: (2022)

Editorial: Molecular modulators of GPCRs signal transduction
por: Vrecl, Milka, et al.
Publicado: (2023)

Yeast Endocytic Adaptor AP-2 Binds the Stress Sensor Mid2 and Functions in Polarized Cell Responses
por: Chapa-y-Lazo, Bernardo, et al.
Publicado: (2014)

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
por: López-Hernández, Tania, et al.
Publicado: (2022)

Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators
por: Garcia-Marcos, Mikel
Publicado: (2021)

Catalytic activation of β-arrestin by GPCRs
por: Eichel, Kelsie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5m0901v4sastcdouqujcugddon