Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals

Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, two proline-rich regions and a C-terminal PDZ (PSD-95, Discs-large, and ZO-1)-binding motif. We, and other groups, have identified various binding partners fo...

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Detalles Bibliográficos
Autores principales: Ito, Hidenori, Morishita, Rika, Nagata, Koh-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073136/
https://www.ncbi.nlm.nih.gov/pubmed/30037057
http://dx.doi.org/10.3390/ijms19072121
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author Ito, Hidenori
Morishita, Rika
Nagata, Koh-ichi
author_facet Ito, Hidenori
Morishita, Rika
Nagata, Koh-ichi
author_sort Ito, Hidenori
collection PubMed
description Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, two proline-rich regions and a C-terminal PDZ (PSD-95, Discs-large, and ZO-1)-binding motif. We, and other groups, have identified various binding partners for Rhotekin and carried out biochemical and cell biological characterization. However, the physiological functions of Rhotekin, per se, are as of yet largely unknown. In this review, we summarize known features of Rhotekin and its binding partners in neuronal tissues and cancer cells.
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spelling pubmed-60731362018-08-13 Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals Ito, Hidenori Morishita, Rika Nagata, Koh-ichi Int J Mol Sci Review Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, two proline-rich regions and a C-terminal PDZ (PSD-95, Discs-large, and ZO-1)-binding motif. We, and other groups, have identified various binding partners for Rhotekin and carried out biochemical and cell biological characterization. However, the physiological functions of Rhotekin, per se, are as of yet largely unknown. In this review, we summarize known features of Rhotekin and its binding partners in neuronal tissues and cancer cells. MDPI 2018-07-20 /pmc/articles/PMC6073136/ /pubmed/30037057 http://dx.doi.org/10.3390/ijms19072121 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ito, Hidenori
Morishita, Rika
Nagata, Koh-ichi
Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals
title Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals
title_full Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals
title_fullStr Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals
title_full_unstemmed Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals
title_short Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals
title_sort functions of rhotekin, an effector of rho gtpase, and its binding partners in mammals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073136/
https://www.ncbi.nlm.nih.gov/pubmed/30037057
http://dx.doi.org/10.3390/ijms19072121
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AT morishitarika functionsofrhotekinaneffectorofrhogtpaseanditsbindingpartnersinmammals
AT nagatakohichi functionsofrhotekinaneffectorofrhogtpaseanditsbindingpartnersinmammals

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