Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways

Simulated-microgravity (SMG) promotes cell-apoptosis. We demonstrated that SMG inhibited cell proliferation/metastasis via FAK/RhoA-regulated mTORC1 pathway. Since mTORC1, NF-κB, and ERK1/2 signaling are important in cell apoptosis, we examined whether SMG-enhanced apoptosis is regulated via these s...

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Detalles Bibliográficos
Autores principales: Zhao, Tuo, Li, Rong, Tan, Xin, Zhang, Jun, Fan, Cuihong, Zhao, Qin, Deng, Yulin, Xu, Aizhang, Lukong, Kiven Erique, Genth, Harald, Xiang, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073227/
https://www.ncbi.nlm.nih.gov/pubmed/29986550
http://dx.doi.org/10.3390/ijms19071994

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