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Celiac Disease and Glandular Autoimmunity

Celiac disease is a small intestinal inflammatory disease with autoimmune features that is triggered and maintained by the ingestion of the storage proteins (gluten) of wheat, barley, and rye. Prevalence of celiac disease is increased in patients with mono- and/or polyglandular autoimmunity and thei...

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Autores principales: Kahaly, George J., Frommer, Lara, Schuppan, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073228/
https://www.ncbi.nlm.nih.gov/pubmed/29941778
http://dx.doi.org/10.3390/nu10070814
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author Kahaly, George J.
Frommer, Lara
Schuppan, Detlef
author_facet Kahaly, George J.
Frommer, Lara
Schuppan, Detlef
author_sort Kahaly, George J.
collection PubMed
description Celiac disease is a small intestinal inflammatory disease with autoimmune features that is triggered and maintained by the ingestion of the storage proteins (gluten) of wheat, barley, and rye. Prevalence of celiac disease is increased in patients with mono- and/or polyglandular autoimmunity and their relatives. We have reviewed the current and pertinent literature that addresses the close association between celiac disease and endocrine autoimmunity. The close relationship between celiac disease and glandular autoimmunity can be largely explained by sharing of a common genetic background. Further, between 10 and 30% of patients with celiac disease are thyroid and/or type 1 diabetes antibody positive, while around 5–7% of patients with autoimmune thyroid disease, type 1 diabetes, and/or polyglandular autoimmunity are IgA anti-tissue transglutaminase antibody positive. While a gluten free diet does not reverse glandular autoimmunity, its early institution may delay or even prevent its first manifestation. In conclusion, this brief review highlighting the close association between celiac disease and both monoglandular and polyglandular autoimmunity, aims to underline the need for prospective studies to establish whether an early diagnosis of celiac disease and a prompt gluten-free diet may positively impact the evolution and manifestation of glandular autoimmunity.
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spelling pubmed-60732282018-08-13 Celiac Disease and Glandular Autoimmunity Kahaly, George J. Frommer, Lara Schuppan, Detlef Nutrients Review Celiac disease is a small intestinal inflammatory disease with autoimmune features that is triggered and maintained by the ingestion of the storage proteins (gluten) of wheat, barley, and rye. Prevalence of celiac disease is increased in patients with mono- and/or polyglandular autoimmunity and their relatives. We have reviewed the current and pertinent literature that addresses the close association between celiac disease and endocrine autoimmunity. The close relationship between celiac disease and glandular autoimmunity can be largely explained by sharing of a common genetic background. Further, between 10 and 30% of patients with celiac disease are thyroid and/or type 1 diabetes antibody positive, while around 5–7% of patients with autoimmune thyroid disease, type 1 diabetes, and/or polyglandular autoimmunity are IgA anti-tissue transglutaminase antibody positive. While a gluten free diet does not reverse glandular autoimmunity, its early institution may delay or even prevent its first manifestation. In conclusion, this brief review highlighting the close association between celiac disease and both monoglandular and polyglandular autoimmunity, aims to underline the need for prospective studies to establish whether an early diagnosis of celiac disease and a prompt gluten-free diet may positively impact the evolution and manifestation of glandular autoimmunity. MDPI 2018-06-25 /pmc/articles/PMC6073228/ /pubmed/29941778 http://dx.doi.org/10.3390/nu10070814 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kahaly, George J.
Frommer, Lara
Schuppan, Detlef
Celiac Disease and Glandular Autoimmunity
title Celiac Disease and Glandular Autoimmunity
title_full Celiac Disease and Glandular Autoimmunity
title_fullStr Celiac Disease and Glandular Autoimmunity
title_full_unstemmed Celiac Disease and Glandular Autoimmunity
title_short Celiac Disease and Glandular Autoimmunity
title_sort celiac disease and glandular autoimmunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073228/
https://www.ncbi.nlm.nih.gov/pubmed/29941778
http://dx.doi.org/10.3390/nu10070814
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