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PD-L1 Nanobody Competitively Inhibits the Formation of the PD-1/PD-L1 Complex: Comparative Molecular Dynamics Simulations

The anti-PD-L1 monoclonal antibody (mAb) targeting PD-1/PD-L1 immune checkpoint has achieved outstanding results in clinical application and has become one of the most popular anti-cancer drugs. The mechanism of molecular recognition and inhibition of PD-L1 mAbs is not yet clear, which hinders the s...

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Detalles Bibliográficos
Autores principales:	Sun, Xin, Yan, Xiao, Zhuo, Wei, Gu, Jinke, Zuo, Ke, Liu, Wei, Liang, Li, Gan, Ya, He, Gang, Wan, Hua, Gou, Xiaojun, Shi, Hubing, Hu, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073277/ https://www.ncbi.nlm.nih.gov/pubmed/29986511 http://dx.doi.org/10.3390/ijms19071984

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