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Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure

The ductus arteriosus (DA) connects the main pulmonary artery and the aorta in fetal circulation and closes spontaneously within days after birth in normal infants. Abnormal patent DA (PDA) causes morbidities and mortality, especially in preterm infants. Closure of the DA is a complex interactive pr...

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Autores principales: Hung, Yu-Chi, Yeh, Jwu-Lai, Hsu, Jong-Hau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073350/
https://www.ncbi.nlm.nih.gov/pubmed/29941785
http://dx.doi.org/10.3390/ijms19071861
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author Hung, Yu-Chi
Yeh, Jwu-Lai
Hsu, Jong-Hau
author_facet Hung, Yu-Chi
Yeh, Jwu-Lai
Hsu, Jong-Hau
author_sort Hung, Yu-Chi
collection PubMed
description The ductus arteriosus (DA) connects the main pulmonary artery and the aorta in fetal circulation and closes spontaneously within days after birth in normal infants. Abnormal patent DA (PDA) causes morbidities and mortality, especially in preterm infants. Closure of the DA is a complex interactive process involving two events: functional and anatomic closure. Functional closure by smooth muscle contraction was achieved through the regulatory factors of vaso-reactivity. These factors include oxygen sensing system, glutamate, osmolality, prostaglandin E(2), nitric oxide, and carbon monoxide. Anatomic closure by vascular remodeling involved several vascular components including endothelium, extracellular matrix, smooth muscle cells, and intraluminal blood cells. Despite advances in understanding of PDA pathogenesis, the molecular mechanism for regulation of DA closure is complex and not fully understood. In this article we review recent evidence regarding the molecular mechanisms of DA closure.
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spelling pubmed-60733502018-08-13 Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure Hung, Yu-Chi Yeh, Jwu-Lai Hsu, Jong-Hau Int J Mol Sci Review The ductus arteriosus (DA) connects the main pulmonary artery and the aorta in fetal circulation and closes spontaneously within days after birth in normal infants. Abnormal patent DA (PDA) causes morbidities and mortality, especially in preterm infants. Closure of the DA is a complex interactive process involving two events: functional and anatomic closure. Functional closure by smooth muscle contraction was achieved through the regulatory factors of vaso-reactivity. These factors include oxygen sensing system, glutamate, osmolality, prostaglandin E(2), nitric oxide, and carbon monoxide. Anatomic closure by vascular remodeling involved several vascular components including endothelium, extracellular matrix, smooth muscle cells, and intraluminal blood cells. Despite advances in understanding of PDA pathogenesis, the molecular mechanism for regulation of DA closure is complex and not fully understood. In this article we review recent evidence regarding the molecular mechanisms of DA closure. MDPI 2018-06-25 /pmc/articles/PMC6073350/ /pubmed/29941785 http://dx.doi.org/10.3390/ijms19071861 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hung, Yu-Chi
Yeh, Jwu-Lai
Hsu, Jong-Hau
Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure
title Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure
title_full Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure
title_fullStr Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure
title_full_unstemmed Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure
title_short Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure
title_sort molecular mechanisms for regulating postnatal ductus arteriosus closure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073350/
https://www.ncbi.nlm.nih.gov/pubmed/29941785
http://dx.doi.org/10.3390/ijms19071861
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