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The Role of Ghrelin in Anorexia Nervosa
Ghrelin, a 28-amino acid peptide hormone expressed in X/A-like endocrine cells of the stomach, is the only known peripherally produced and centrally acting peptide that stimulates food intake and therefore attracted a lot of attention with one major focus on the treatment of conditions where an incr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073411/ https://www.ncbi.nlm.nih.gov/pubmed/30037011 http://dx.doi.org/10.3390/ijms19072117 |
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author | Schalla, Martha A. Stengel, Andreas |
author_facet | Schalla, Martha A. Stengel, Andreas |
author_sort | Schalla, Martha A. |
collection | PubMed |
description | Ghrelin, a 28-amino acid peptide hormone expressed in X/A-like endocrine cells of the stomach, is the only known peripherally produced and centrally acting peptide that stimulates food intake and therefore attracted a lot of attention with one major focus on the treatment of conditions where an increased energy intake or body weight gain is desired. Anorexia nervosa is an eating disorder characterized by a pronounced reduction of body weight, a disturbed body image and hormonal alterations. Ghrelin signaling has been thoroughly investigated under conditions of anorexia nervosa. The present review will highlight these alterations of ghrelin in anorexia and discuss possible treatment strategies targeting ghrelin signaling. Lastly, gaps in knowledge will be mentioned to foster future research. |
format | Online Article Text |
id | pubmed-6073411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60734112018-08-13 The Role of Ghrelin in Anorexia Nervosa Schalla, Martha A. Stengel, Andreas Int J Mol Sci Review Ghrelin, a 28-amino acid peptide hormone expressed in X/A-like endocrine cells of the stomach, is the only known peripherally produced and centrally acting peptide that stimulates food intake and therefore attracted a lot of attention with one major focus on the treatment of conditions where an increased energy intake or body weight gain is desired. Anorexia nervosa is an eating disorder characterized by a pronounced reduction of body weight, a disturbed body image and hormonal alterations. Ghrelin signaling has been thoroughly investigated under conditions of anorexia nervosa. The present review will highlight these alterations of ghrelin in anorexia and discuss possible treatment strategies targeting ghrelin signaling. Lastly, gaps in knowledge will be mentioned to foster future research. MDPI 2018-07-20 /pmc/articles/PMC6073411/ /pubmed/30037011 http://dx.doi.org/10.3390/ijms19072117 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schalla, Martha A. Stengel, Andreas The Role of Ghrelin in Anorexia Nervosa |
title | The Role of Ghrelin in Anorexia Nervosa |
title_full | The Role of Ghrelin in Anorexia Nervosa |
title_fullStr | The Role of Ghrelin in Anorexia Nervosa |
title_full_unstemmed | The Role of Ghrelin in Anorexia Nervosa |
title_short | The Role of Ghrelin in Anorexia Nervosa |
title_sort | role of ghrelin in anorexia nervosa |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073411/ https://www.ncbi.nlm.nih.gov/pubmed/30037011 http://dx.doi.org/10.3390/ijms19072117 |
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