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Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications
Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The ob...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073476/ https://www.ncbi.nlm.nih.gov/pubmed/30002342 http://dx.doi.org/10.3390/nu10070892 |
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author | Hoffmanová, Iva Sánchez, Daniel Tučková, Ludmila Tlaskalová-Hogenová, Helena |
author_facet | Hoffmanová, Iva Sánchez, Daniel Tučková, Ludmila Tlaskalová-Hogenová, Helena |
author_sort | Hoffmanová, Iva |
collection | PubMed |
description | Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut–liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease. |
format | Online Article Text |
id | pubmed-6073476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60734762018-08-13 Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications Hoffmanová, Iva Sánchez, Daniel Tučková, Ludmila Tlaskalová-Hogenová, Helena Nutrients Review Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut–liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease. MDPI 2018-07-12 /pmc/articles/PMC6073476/ /pubmed/30002342 http://dx.doi.org/10.3390/nu10070892 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hoffmanová, Iva Sánchez, Daniel Tučková, Ludmila Tlaskalová-Hogenová, Helena Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications |
title | Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications |
title_full | Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications |
title_fullStr | Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications |
title_full_unstemmed | Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications |
title_short | Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications |
title_sort | celiac disease and liver disorders: from putative pathogenesis to clinical implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073476/ https://www.ncbi.nlm.nih.gov/pubmed/30002342 http://dx.doi.org/10.3390/nu10070892 |
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