Cargando…

The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer

Pancreatic cancer (PaCa) is the fourth leading cause of cancer-related death, and personalized targeted cancer therapy is becoming a promising treatment strategy for PaCa. The central approach of targeted therapy is to find a targetable key and an effective targeting method. In this study, the impor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Bin, Yang, Hai, Pilarsky, Christian, Weber, Georg F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073545/ https://www.ncbi.nlm.nih.gov/pubmed/29949874 http://dx.doi.org/10.3390/ijms19071870

Ejemplares similares

Addendum: Liu, B. et al. The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer. Int. J. Mol. Sci. 2018, 19, 1870
por: Liu, Bin, et al.
Publicado: (2019)

Upregulated GPRC5A disrupting the Hippo pathway promotes the proliferation and migration of pancreatic cancer cells via the cAMP-CREB axis
por: Fang, Weidan, et al.
Publicado: (2023)

Phosphorylation of LCRMP-1 by GSK3β Promotes Filopoda Formation, Migration and Invasion Abilities in Lung Cancer Cells
por: Wang, Wen-Lung, et al.
Publicado: (2012)

EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer
por: Lin, Xiaofeng, et al.
Publicado: (2014)

Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a
por: Wei, Jianwen, et al.
Publicado: (2014)

RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A
por: Richter, Lukas, et al.
Publicado: (2020)

circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide
por: Gu, Chaohui, et al.
Publicado: (2018)

20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway
por: Lin, Kaili, et al.
Publicado: (2020)

miR-342 inhibits glioma cell proliferation by targeting GPRC5A
por: Wang, Jianjiao, et al.
Publicado: (2019)

The emerging roles of GPRC5A in diseases
por: Zhou, Honglei, et al.
Publicado: (2014)

The G Protein-Coupled Receptor RAI3 Is an Independent Prognostic Factor for Pancreatic Cancer Survival and Regulates Proliferation via STAT3 Phosphorylation
por: Jahny, Elisabeth, et al.
Publicado: (2017)

GPRC5B-Mediated Sphingomyelin Synthase 2 Phosphorylation Plays a Critical Role in Insulin Resistance
por: Kim, Yeon-Jeong, et al.
Publicado: (2018)

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
por: Gozdz, Agata, et al.
Publicado: (2017)

GPRC5A: An Emerging Biomarker in Human Cancer
por: Jiang, Xiaoxia, et al.
Publicado: (2018)

GPRC5A: An emerging prognostic biomarker for predicting malignancy of Pancreatic Cancer based on bioinformatics analysis
por: Qian, Xuetian, et al.
Publicado: (2021)

IMUP and GPRC5A: two newly identified risk score indicators in pancreatic ductal adenocarcinoma
por: Wei, Rong, et al.
Publicado: (2021)

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis
por: Moore, Samantha F., et al.
Publicado: (2021)

Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer
por: Liu, Bin, et al.
Publicado: (2018)

MiR-103a-3p targets the 5′ UTR of GPRC5A in pancreatic cells
por: Zhou, Honglei, et al.
Publicado: (2014)

GPRC5B protects osteoarthritis by regulation of autophagy signaling
por: He, Liang, et al.
Publicado: (2023)

Overexpression of FBXO17 Promotes the Proliferation, Migration and Invasion of Glioma Cells Through the Akt/GSK-3β/Snail Pathway
por: Wang, Ning, et al.
Publicado: (2021)

Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer
por: Moyano‐Galceran, Lidia, et al.
Publicado: (2020)

Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity
por: Zhang, Shi Qing, et al.
Publicado: (2018)

GSK3β Inhibition by Phosphorylation at Ser(389) Controls Neuroinflammation
por: Calvo, Belen, et al.
Publicado: (2022)

Computationally identified novel agonists for GPRC6A
por: Pi, Min, et al.
Publicado: (2018)

Upregulated IQUB promotes cell proliferation and migration via activating Akt/GSK3β/β‐catenin signaling pathway in breast cancer
por: Li, Kai, et al.
Publicado: (2018)

Chemoresistance in Pancreatic Cancer
por: Zeng, Siyuan, et al.
Publicado: (2019)

Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/β-catenin pathway
por: Pratap, Akshay, et al.
Publicado: (2022)

Correction: Oleanolic acid enhances neural stem cell migration, proliferation and differentiation in vitro by inhibiting GSK3β activity
por: Zhang, Shi Qing, et al.
Publicado: (2021)

Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions
por: Brunner, Maximilian, et al.
Publicado: (2019)

CRISPR Cas9 in Pancreatic Cancer Research
por: Yang, Hai, et al.
Publicado: (2019)

Phosphorylation of the Cytoskeletal Protein CAP1 Regulates Non-Small Cell Lung Cancer Survival and Proliferation by GSK3β
por: Xie, Shuanshuan, et al.
Publicado: (2018)

GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR
por: Zhou, H, et al.
Publicado: (2016)

Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2
por: Kato, Akihisa, et al.
Publicado: (2015)

Tau phosphorylation by GSK-3β promotes tangle-like filament morphology
por: Rankin, Carolyn A, et al.
Publicado: (2007)

β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling
por: Maher, Meghan T., et al.
Publicado: (2010)

Lemur tyrosine kinase 2 silencing inhibits the proliferation of gastric cancer cells by regulating GSK-3β phosphorylation and β-catenin nuclear translocation
por: Han, Xin, et al.
Publicado: (2022)

Impaired Osteoblast Function in GPRC6A Null Mice
por: Pi, Min, et al.
Publicado: (2010)

GPRC6A: Jack of all metabolism (or master of none)
por: Pi, Min, et al.
Publicado: (2016)

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6
por: Wu, Geng, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_h5t9f4pf57rprrrh8fq13v4sgh