Cargando…

Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review

Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. Oxidative stress has numerous effects, inc...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahman, Sajid Ur, Huang, Yingying, Zhu, Lei, Feng, Shibin, Khan, Ibrar Muhammad, Wu, Jinjie, Li, Yu, Wang, Xichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073549/
https://www.ncbi.nlm.nih.gov/pubmed/29954124
http://dx.doi.org/10.3390/nu10070834
_version_ 1783344216370315264
author Rahman, Sajid Ur
Huang, Yingying
Zhu, Lei
Feng, Shibin
Khan, Ibrar Muhammad
Wu, Jinjie
Li, Yu
Wang, Xichun
author_facet Rahman, Sajid Ur
Huang, Yingying
Zhu, Lei
Feng, Shibin
Khan, Ibrar Muhammad
Wu, Jinjie
Li, Yu
Wang, Xichun
author_sort Rahman, Sajid Ur
collection PubMed
description Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. Oxidative stress has numerous effects, including increased apoptosis, reduced motion parameters, and reduced sperm integrity. In this regard, green tea polyphenols (GrTPs) have been reported to possess properties that may increase the quality of male and female gametes, mostly via the capability of catechins to reduce ROS production. GrTPs have antioxidant properties that improve major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality. These unique properties of green tea catechins could improve reproductive health and represent an important study area. This exploratory review discusses the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals.
format Online
Article
Text
id pubmed-6073549
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60735492018-08-13 Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review Rahman, Sajid Ur Huang, Yingying Zhu, Lei Feng, Shibin Khan, Ibrar Muhammad Wu, Jinjie Li, Yu Wang, Xichun Nutrients Review Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. Oxidative stress has numerous effects, including increased apoptosis, reduced motion parameters, and reduced sperm integrity. In this regard, green tea polyphenols (GrTPs) have been reported to possess properties that may increase the quality of male and female gametes, mostly via the capability of catechins to reduce ROS production. GrTPs have antioxidant properties that improve major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality. These unique properties of green tea catechins could improve reproductive health and represent an important study area. This exploratory review discusses the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals. MDPI 2018-06-27 /pmc/articles/PMC6073549/ /pubmed/29954124 http://dx.doi.org/10.3390/nu10070834 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rahman, Sajid Ur
Huang, Yingying
Zhu, Lei
Feng, Shibin
Khan, Ibrar Muhammad
Wu, Jinjie
Li, Yu
Wang, Xichun
Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
title Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
title_full Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
title_fullStr Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
title_full_unstemmed Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
title_short Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review
title_sort therapeutic role of green tea polyphenols in improving fertility: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073549/
https://www.ncbi.nlm.nih.gov/pubmed/29954124
http://dx.doi.org/10.3390/nu10070834
work_keys_str_mv AT rahmansajidur therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview
AT huangyingying therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview
AT zhulei therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview
AT fengshibin therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview
AT khanibrarmuhammad therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview
AT wujinjie therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview
AT liyu therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview
AT wangxichun therapeuticroleofgreenteapolyphenolsinimprovingfertilityareview