Cargando…
Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections
Acute infectious gastroenteritis (GE) and urinary tract infection (UTI) are common diseases and are normally perceived as mild and limiting illnesses. Xyloglucan is a natural plant polymer with protective barrier properties, also known as “mucosal protectors”, which is the main ingredient of medical...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073600/ https://www.ncbi.nlm.nih.gov/pubmed/29932149 http://dx.doi.org/10.3390/ijms19071844 |
_version_ | 1783344227778822144 |
---|---|
author | Esposito, Emanuela Campolo, Michela Casili, Giovanna Lanza, Marika Franco, Domenico Filippone, Alessia Peritore, Alessio F. Cuzzocrea, Salvatore |
author_facet | Esposito, Emanuela Campolo, Michela Casili, Giovanna Lanza, Marika Franco, Domenico Filippone, Alessia Peritore, Alessio F. Cuzzocrea, Salvatore |
author_sort | Esposito, Emanuela |
collection | PubMed |
description | Acute infectious gastroenteritis (GE) and urinary tract infection (UTI) are common diseases and are normally perceived as mild and limiting illnesses. Xyloglucan is a natural plant polymer with protective barrier properties, also known as “mucosal protectors”, which is the main ingredient of medical devices developed for the management of different diseases, such as gastrointestinal diseases, urinary tract infections, or respiratory allergic diseases. The aim of this study was to evaluate the protective effect of xyloglucan in association with gelose (also called agar) in an experimental model of bacterial GE and UTI in rats. Two kinds of infection were induced by oral administration of Salmonella enterica and Enterococcus hirae for three days. Two days before the bacterial administration, preventive oral treatment with xyloglucan + gelose (10 mg/kg + 5 mg/kg) was performed daily until the seventh day. Twenty-four hours after the last treatment, rats were sacrificed and urinary tracts and intestines for different analysis were collected. The results showed that xyloglucan plus gelose was able to reduce intestinal morphological changes (p < 0.05 for both), tight junctions (TJ) permeability (p < 0.001 for both), and neutrophil infiltration (p < 0.05 for both) induced by bacterial infections, highlighting its barrier proprieties. Moreover, the compound reduced the number of bacterial colonies in the urinary tract favoring elimination by feces. The results obtained in the present study suggest that the protective barrier properties of xyloglucan plus gelose allow the prevention of GE and UTI in models of infections in rats. |
format | Online Article Text |
id | pubmed-6073600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60736002018-08-13 Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections Esposito, Emanuela Campolo, Michela Casili, Giovanna Lanza, Marika Franco, Domenico Filippone, Alessia Peritore, Alessio F. Cuzzocrea, Salvatore Int J Mol Sci Article Acute infectious gastroenteritis (GE) and urinary tract infection (UTI) are common diseases and are normally perceived as mild and limiting illnesses. Xyloglucan is a natural plant polymer with protective barrier properties, also known as “mucosal protectors”, which is the main ingredient of medical devices developed for the management of different diseases, such as gastrointestinal diseases, urinary tract infections, or respiratory allergic diseases. The aim of this study was to evaluate the protective effect of xyloglucan in association with gelose (also called agar) in an experimental model of bacterial GE and UTI in rats. Two kinds of infection were induced by oral administration of Salmonella enterica and Enterococcus hirae for three days. Two days before the bacterial administration, preventive oral treatment with xyloglucan + gelose (10 mg/kg + 5 mg/kg) was performed daily until the seventh day. Twenty-four hours after the last treatment, rats were sacrificed and urinary tracts and intestines for different analysis were collected. The results showed that xyloglucan plus gelose was able to reduce intestinal morphological changes (p < 0.05 for both), tight junctions (TJ) permeability (p < 0.001 for both), and neutrophil infiltration (p < 0.05 for both) induced by bacterial infections, highlighting its barrier proprieties. Moreover, the compound reduced the number of bacterial colonies in the urinary tract favoring elimination by feces. The results obtained in the present study suggest that the protective barrier properties of xyloglucan plus gelose allow the prevention of GE and UTI in models of infections in rats. MDPI 2018-06-22 /pmc/articles/PMC6073600/ /pubmed/29932149 http://dx.doi.org/10.3390/ijms19071844 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Esposito, Emanuela Campolo, Michela Casili, Giovanna Lanza, Marika Franco, Domenico Filippone, Alessia Peritore, Alessio F. Cuzzocrea, Salvatore Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections |
title | Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections |
title_full | Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections |
title_fullStr | Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections |
title_full_unstemmed | Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections |
title_short | Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections |
title_sort | protective effects of xyloglucan in association with the polysaccharide gelose in an experimental model of gastroenteritis and urinary tract infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073600/ https://www.ncbi.nlm.nih.gov/pubmed/29932149 http://dx.doi.org/10.3390/ijms19071844 |
work_keys_str_mv | AT espositoemanuela protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections AT campolomichela protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections AT casiligiovanna protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections AT lanzamarika protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections AT francodomenico protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections AT filipponealessia protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections AT peritorealessiof protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections AT cuzzocreasalvatore protectiveeffectsofxyloglucaninassociationwiththepolysaccharidegeloseinanexperimentalmodelofgastroenteritisandurinarytractinfections |