Cargando…
Foxn1 in Skin Development, Homeostasis and Wound Healing
Intensive research effort has focused on cellular and molecular mechanisms that regulate skin biology, including the phenomenon of scar-free skin healing during foetal life. Transcription factors are the key molecules that tune gene expression and either promote or suppress gene transcription. The e...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073674/ https://www.ncbi.nlm.nih.gov/pubmed/29973508 http://dx.doi.org/10.3390/ijms19071956 |
_version_ | 1783344241465884672 |
---|---|
author | Bukowska, Joanna Kopcewicz, Marta Walendzik, Katarzyna Gawronska-Kozak, Barbara |
author_facet | Bukowska, Joanna Kopcewicz, Marta Walendzik, Katarzyna Gawronska-Kozak, Barbara |
author_sort | Bukowska, Joanna |
collection | PubMed |
description | Intensive research effort has focused on cellular and molecular mechanisms that regulate skin biology, including the phenomenon of scar-free skin healing during foetal life. Transcription factors are the key molecules that tune gene expression and either promote or suppress gene transcription. The epidermis is the source of transcription factors that regulate many functions of epidermal cells such as proliferation, differentiation, apoptosis, and migration. Furthermore, the activation of epidermal transcription factors also causes changes in the dermal compartment of the skin. This review focuses on the transcription factor Foxn1 and its role in skin biology. The regulatory function of Foxn1 in the skin relates to physiological (development and homeostasis) and pathological (skin wound healing) conditions. In particular, the pivotal role of Foxn1 in skin development and the acquisition of the adult skin phenotype, which coincides with losing the ability of scar-free healing, is discussed. Thus, genetic manipulations with Foxn1 expression, specifically those introducing conditional Foxn1 silencing in a Foxn1+/+ organism or its knock-in in a Foxn1−/− model, may provide future perspectives for regenerative medicine. |
format | Online Article Text |
id | pubmed-6073674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60736742018-08-13 Foxn1 in Skin Development, Homeostasis and Wound Healing Bukowska, Joanna Kopcewicz, Marta Walendzik, Katarzyna Gawronska-Kozak, Barbara Int J Mol Sci Review Intensive research effort has focused on cellular and molecular mechanisms that regulate skin biology, including the phenomenon of scar-free skin healing during foetal life. Transcription factors are the key molecules that tune gene expression and either promote or suppress gene transcription. The epidermis is the source of transcription factors that regulate many functions of epidermal cells such as proliferation, differentiation, apoptosis, and migration. Furthermore, the activation of epidermal transcription factors also causes changes in the dermal compartment of the skin. This review focuses on the transcription factor Foxn1 and its role in skin biology. The regulatory function of Foxn1 in the skin relates to physiological (development and homeostasis) and pathological (skin wound healing) conditions. In particular, the pivotal role of Foxn1 in skin development and the acquisition of the adult skin phenotype, which coincides with losing the ability of scar-free healing, is discussed. Thus, genetic manipulations with Foxn1 expression, specifically those introducing conditional Foxn1 silencing in a Foxn1+/+ organism or its knock-in in a Foxn1−/− model, may provide future perspectives for regenerative medicine. MDPI 2018-07-04 /pmc/articles/PMC6073674/ /pubmed/29973508 http://dx.doi.org/10.3390/ijms19071956 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bukowska, Joanna Kopcewicz, Marta Walendzik, Katarzyna Gawronska-Kozak, Barbara Foxn1 in Skin Development, Homeostasis and Wound Healing |
title | Foxn1 in Skin Development, Homeostasis and Wound Healing |
title_full | Foxn1 in Skin Development, Homeostasis and Wound Healing |
title_fullStr | Foxn1 in Skin Development, Homeostasis and Wound Healing |
title_full_unstemmed | Foxn1 in Skin Development, Homeostasis and Wound Healing |
title_short | Foxn1 in Skin Development, Homeostasis and Wound Healing |
title_sort | foxn1 in skin development, homeostasis and wound healing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073674/ https://www.ncbi.nlm.nih.gov/pubmed/29973508 http://dx.doi.org/10.3390/ijms19071956 |
work_keys_str_mv | AT bukowskajoanna foxn1inskindevelopmenthomeostasisandwoundhealing AT kopcewiczmarta foxn1inskindevelopmenthomeostasisandwoundhealing AT walendzikkatarzyna foxn1inskindevelopmenthomeostasisandwoundhealing AT gawronskakozakbarbara foxn1inskindevelopmenthomeostasisandwoundhealing |