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Foxn1 in Skin Development, Homeostasis and Wound Healing

Intensive research effort has focused on cellular and molecular mechanisms that regulate skin biology, including the phenomenon of scar-free skin healing during foetal life. Transcription factors are the key molecules that tune gene expression and either promote or suppress gene transcription. The e...

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Autores principales: Bukowska, Joanna, Kopcewicz, Marta, Walendzik, Katarzyna, Gawronska-Kozak, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073674/
https://www.ncbi.nlm.nih.gov/pubmed/29973508
http://dx.doi.org/10.3390/ijms19071956
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author Bukowska, Joanna
Kopcewicz, Marta
Walendzik, Katarzyna
Gawronska-Kozak, Barbara
author_facet Bukowska, Joanna
Kopcewicz, Marta
Walendzik, Katarzyna
Gawronska-Kozak, Barbara
author_sort Bukowska, Joanna
collection PubMed
description Intensive research effort has focused on cellular and molecular mechanisms that regulate skin biology, including the phenomenon of scar-free skin healing during foetal life. Transcription factors are the key molecules that tune gene expression and either promote or suppress gene transcription. The epidermis is the source of transcription factors that regulate many functions of epidermal cells such as proliferation, differentiation, apoptosis, and migration. Furthermore, the activation of epidermal transcription factors also causes changes in the dermal compartment of the skin. This review focuses on the transcription factor Foxn1 and its role in skin biology. The regulatory function of Foxn1 in the skin relates to physiological (development and homeostasis) and pathological (skin wound healing) conditions. In particular, the pivotal role of Foxn1 in skin development and the acquisition of the adult skin phenotype, which coincides with losing the ability of scar-free healing, is discussed. Thus, genetic manipulations with Foxn1 expression, specifically those introducing conditional Foxn1 silencing in a Foxn1+/+ organism or its knock-in in a Foxn1−/− model, may provide future perspectives for regenerative medicine.
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spelling pubmed-60736742018-08-13 Foxn1 in Skin Development, Homeostasis and Wound Healing Bukowska, Joanna Kopcewicz, Marta Walendzik, Katarzyna Gawronska-Kozak, Barbara Int J Mol Sci Review Intensive research effort has focused on cellular and molecular mechanisms that regulate skin biology, including the phenomenon of scar-free skin healing during foetal life. Transcription factors are the key molecules that tune gene expression and either promote or suppress gene transcription. The epidermis is the source of transcription factors that regulate many functions of epidermal cells such as proliferation, differentiation, apoptosis, and migration. Furthermore, the activation of epidermal transcription factors also causes changes in the dermal compartment of the skin. This review focuses on the transcription factor Foxn1 and its role in skin biology. The regulatory function of Foxn1 in the skin relates to physiological (development and homeostasis) and pathological (skin wound healing) conditions. In particular, the pivotal role of Foxn1 in skin development and the acquisition of the adult skin phenotype, which coincides with losing the ability of scar-free healing, is discussed. Thus, genetic manipulations with Foxn1 expression, specifically those introducing conditional Foxn1 silencing in a Foxn1+/+ organism or its knock-in in a Foxn1−/− model, may provide future perspectives for regenerative medicine. MDPI 2018-07-04 /pmc/articles/PMC6073674/ /pubmed/29973508 http://dx.doi.org/10.3390/ijms19071956 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bukowska, Joanna
Kopcewicz, Marta
Walendzik, Katarzyna
Gawronska-Kozak, Barbara
Foxn1 in Skin Development, Homeostasis and Wound Healing
title Foxn1 in Skin Development, Homeostasis and Wound Healing
title_full Foxn1 in Skin Development, Homeostasis and Wound Healing
title_fullStr Foxn1 in Skin Development, Homeostasis and Wound Healing
title_full_unstemmed Foxn1 in Skin Development, Homeostasis and Wound Healing
title_short Foxn1 in Skin Development, Homeostasis and Wound Healing
title_sort foxn1 in skin development, homeostasis and wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073674/
https://www.ncbi.nlm.nih.gov/pubmed/29973508
http://dx.doi.org/10.3390/ijms19071956
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