Cargando…

Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction

The growth hormone (GH) plays a key role in the regulation of metabolic processes in an organism. Determination of the correct structure and functioning of the growth hormone receptor (GHR) allowed for a more detailed research of its post-receptor regulators, which substantially influences its signa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wójcik, Maciej, Krawczyńska, Agata, Antushevich, Hanna, Herman, Andrzej Przemysław
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073700/ https://www.ncbi.nlm.nih.gov/pubmed/29932147 http://dx.doi.org/10.3390/ijms19071843

Ejemplares similares

Influence of Leptin on the Secretion of Growth Hormone in Ewes under Different Photoperiodic Conditions
por: Wójcik, Maciej, et al.
Publicado: (2023)

The Effect of Leptin on the Blood Hormonal Profile (Cortisol, Insulin, Thyroid Hormones) of the Ewe in Acute Inflammation in Two Different Photoperiodical Conditions
por: Krawczyńska, Agata, et al.
Publicado: (2022)

Acute Effect of Caffeine on the Synthesis of Pro-Inflammatory Cytokines in the Hypothalamus and Choroid Plexus during Endotoxin-Induced Inflammation in a Female Sheep Model
por: Szczepkowska, Aleksandra, et al.
Publicado: (2021)

Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation
por: Herman, Andrzej P., et al.
Publicado: (2018)

The Impact of Photoperiod on the Leptin Sensitivity and Course of Inflammation in the Anterior Pituitary
por: Wójcik, Maciej, et al.
Publicado: (2020)

Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus
por: Herman, Andrzej P., et al.
Publicado: (2014)

Effect of Central Injection of Neostigmine on the Bacterial Endotoxin Induced Suppression of GnRH/LH Secretion in Ewes during the Follicular Phase of the Estrous Cycle
por: Herman, Andrzej Przemysław, et al.
Publicado: (2019)

The Influence of Photoperiod on the Action of Exogenous Leptin on Gene Expression of Proinflammatory Cytokines and Their Receptors in the Thoracic Perivascular Adipose Tissue (PVAT) in Ewes
por: Krawczyńska, Agata, et al.
Publicado: (2019)

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice
por: List, Edward O., et al.
Publicado: (2015)

Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle
por: Herman, Andrzej P., et al.
Publicado: (2017)

Endotoxin-induced inflammation disturbs melatonin secretion in ewe
por: Herman, Andrzej Przemysław, et al.
Publicado: (2017)

The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism—A Favorable Backdoor Mechanism for the GHR Function
por: Falah, Ghadeer, et al.
Publicado: (2023)

Effect of Acute and Prolonged Inflammation on the Gene Expression of Proinflammatory Cytokines and Their Receptors in the Anterior Pituitary Gland of Ewes
por: Wojtulewicz, Karolina, et al.
Publicado: (2020)

Identification of the cDNA Encoding the Growth Hormone Receptor (GHR) and the Regulation of GHR and IGF-I Gene Expression by Nutritional Status in Reeves’ Turtle (Chinemys reevesii)
por: Zhu, Wenlu, et al.
Publicado: (2020)

Growth Hormone Receptor (GHR) 6Ω Pseudoexon Activation: A Novel Cause of Severe Growth Hormone Insensitivity
por: Cottrell, Emily, et al.
Publicado: (2021)

Association study between growth hormone receptor (GHR ) gene polymorphisms and obesity in Korean population
por: Yang, Seung-Ae
Publicado: (2016)

Chicken GHR natural antisense transcript regulates GHR mRNA in LMH cells
por: Zhang, Li, et al.
Publicado: (2016)

Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature
por: Dias, Christel, et al.
Publicado: (2017)

A novel GHR variant in the first patient of Indian origin with genetically proven growth hormone insensitivity
por: Nikith, Zagabathina Siddu, et al.
Publicado: (2022)

Tissue-Specific GHR Knockout Mice: Metabolic Phenotypes
por: Sun, Liou Y., et al.
Publicado: (2015)

The Influence of Diet Containing Wheat Gluten Supplemented with Dipeptides or Amino Acids on the Morphology of White Muscle of Yellow Perch (Perca flavescens)
por: Kamaszewski, Maciej, et al.
Publicado: (2020)

SUN-336 Autocrine / Paracrine Growth Hormone (GH) Drives Multimodal Therapy Resistance in Growth Hormone Receptor (GHR)-expressing Human Cancers
por: Basu, Reetobrata, et al.
Publicado: (2019)

Correlative study on the JAK-STAT/PSMβ3 signal transduction pathway in asthenozoospermia
por: Li, Junguo, et al.
Publicado: (2017)

JAK-STAT pathway inhibitors in dermatology()
por: Miot, Hélio Amante, et al.
Publicado: (2023)

Deletion of hepatic growth hormone receptor (GHR) alters the mouse gut microbiota by affecting bile acid metabolism
por: Yu, Zichao, et al.
Publicado: (2023)

Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging
por: Arum, Oge, et al.
Publicado: (2014)

GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients
por: Chatterjee, Sumana, et al.
Publicado: (2020)

SAT-LB054 Growth Hormone Receptor (GHR) Antagonism Suppresses Hepatocellular Carcinoma Growth in a Syngeneic Mouse Model
por: Mathes, Samuel, et al.
Publicado: (2019)

A Recurrent Mutation in Growth Hormone Receptor (GHR) Gene Underlying Laron-type Dwarfism in a Pakistani Family
por: Shabbir, Rana Muhammad Kamran, et al.
Publicado: (2023)

Methotrexate Is a JAK/STAT Pathway Inhibitor
por: Thomas, Sally, et al.
Publicado: (2015)

Intracellular Signaling Transduction Pathways Triggered by a Well-Known Anti-GHR Monoclonal Antibody, Mab263, in Vitro and in Vivo
por: Lan, Hainan, et al.
Publicado: (2014)

LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants
por: Herman, Andrzej Przemysław, et al.
Publicado: (2013)

Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
por: Furqan, Muhammad, et al.
Publicado: (2013)

Cholangiocarcinoma cells secrete soluble factors that activate Jak/STAT signal transduction and promote MDSC expansion
por: Yang, Jennifer, et al.
Publicado: (2014)

Mutations Affecting Mammalian Aging: GH and GHR vs IGF-1 and Insulin
por: Bartke, Andrzej, et al.
Publicado: (2021)

Association of GHR Polymorphisms with Milk Production in Buffaloes
por: El-Komy, Shymaa M., et al.
Publicado: (2020)

Hypothalamic GHR—SIRT1 Axis in Fasting
por: de Lima, Juliana Bezerra Medeiros, et al.
Publicado: (2021)

The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders
por: Caiazzo, Giuseppina, et al.
Publicado: (2023)

Heterodimeric JAK-STAT Activation as a Mechanism of Persistence to JAK2 Inhibitor Therapy
por: Koppikar, Priya, et al.
Publicado: (2012)

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
por: Boyle, D L, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_nhnhljcbocesp43hfb7ak4rv2b