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Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice

The glycaemic index (GI) is a useful tool to compare the glycaemic responses of foods. Numerous studies report the favorable effects of low GI diets on long term metabolic health compared with high GI diets. However, it has not been possible to link these effects to the GI itself because of other co...

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Autores principales: Campbell, Grace J., Belobrajdic, Damien P., Bell-Anderson, Kim S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073758/
https://www.ncbi.nlm.nih.gov/pubmed/29966395
http://dx.doi.org/10.3390/nu10070856
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author Campbell, Grace J.
Belobrajdic, Damien P.
Bell-Anderson, Kim S.
author_facet Campbell, Grace J.
Belobrajdic, Damien P.
Bell-Anderson, Kim S.
author_sort Campbell, Grace J.
collection PubMed
description The glycaemic index (GI) is a useful tool to compare the glycaemic responses of foods. Numerous studies report the favorable effects of low GI diets on long term metabolic health compared with high GI diets. However, it has not been possible to link these effects to the GI itself because of other components such as macronutrients and dietary fibre, which are known to affect GI. This study aimed to create and evaluate isocaloric diets differing in GI independent of macronutrient and fibre content. The GIs of eight diets differing in carbohydrate source were evaluated in mice; cooked cornstarch (CC), raw cornstarch (RC), chow, maltodextrin, glucose, sucrose, isomaltulose, and fructose. A glucose control was also tested. The GIs of all eight diets were different from the GI of the glucose control (GI: 100; p < 0.0001). The GIs of the glucose (mean ± SEM: 52 ± 3), maltodextrin (52 ± 6), CC (50 ± 4), RC (50 ± 6), and chow (44 ± 4) diets were similar, while the GIs of the sucrose (31 ± 4), isomaltulose (24 ± 5), and fructose (18 ± 2) diets were lower than all other diets (p < 0.05). This is the first trial to report GI testing in vivo in mice, resulting in three main findings: chow is relatively high GI, the glucose availability of raw and cooked cornstarch is similar, and the GI of different sugar diets occur in the same rank order as in humans.
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spelling pubmed-60737582018-08-13 Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice Campbell, Grace J. Belobrajdic, Damien P. Bell-Anderson, Kim S. Nutrients Article The glycaemic index (GI) is a useful tool to compare the glycaemic responses of foods. Numerous studies report the favorable effects of low GI diets on long term metabolic health compared with high GI diets. However, it has not been possible to link these effects to the GI itself because of other components such as macronutrients and dietary fibre, which are known to affect GI. This study aimed to create and evaluate isocaloric diets differing in GI independent of macronutrient and fibre content. The GIs of eight diets differing in carbohydrate source were evaluated in mice; cooked cornstarch (CC), raw cornstarch (RC), chow, maltodextrin, glucose, sucrose, isomaltulose, and fructose. A glucose control was also tested. The GIs of all eight diets were different from the GI of the glucose control (GI: 100; p < 0.0001). The GIs of the glucose (mean ± SEM: 52 ± 3), maltodextrin (52 ± 6), CC (50 ± 4), RC (50 ± 6), and chow (44 ± 4) diets were similar, while the GIs of the sucrose (31 ± 4), isomaltulose (24 ± 5), and fructose (18 ± 2) diets were lower than all other diets (p < 0.05). This is the first trial to report GI testing in vivo in mice, resulting in three main findings: chow is relatively high GI, the glucose availability of raw and cooked cornstarch is similar, and the GI of different sugar diets occur in the same rank order as in humans. MDPI 2018-07-01 /pmc/articles/PMC6073758/ /pubmed/29966395 http://dx.doi.org/10.3390/nu10070856 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Campbell, Grace J.
Belobrajdic, Damien P.
Bell-Anderson, Kim S.
Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice
title Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice
title_full Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice
title_fullStr Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice
title_full_unstemmed Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice
title_short Determining the Glycaemic Index of Standard and High-Sugar Rodent Diets in C57BL/6 Mice
title_sort determining the glycaemic index of standard and high-sugar rodent diets in c57bl/6 mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073758/
https://www.ncbi.nlm.nih.gov/pubmed/29966395
http://dx.doi.org/10.3390/nu10070856
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