Role of mTOR in Glucose and Lipid Metabolism

The mammalian target of rapamycin, mTOR is the master regulator of a cell’s growth and metabolic state in response to nutrients, growth factors and many extracellular cues. Its dysregulation leads to a number of metabolic pathological conditions, including obesity and type 2 diabetes. Here, we revie...

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Detalles Bibliográficos
Autores principales: Mao, Zhuo, Zhang, Weizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073766/
https://www.ncbi.nlm.nih.gov/pubmed/30011848
http://dx.doi.org/10.3390/ijms19072043
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author Mao, Zhuo
Zhang, Weizhen
author_facet Mao, Zhuo
Zhang, Weizhen
author_sort Mao, Zhuo
collection PubMed
description The mammalian target of rapamycin, mTOR is the master regulator of a cell’s growth and metabolic state in response to nutrients, growth factors and many extracellular cues. Its dysregulation leads to a number of metabolic pathological conditions, including obesity and type 2 diabetes. Here, we review recent findings on the role of mTOR in major metabolic organs, such as adipose tissues, liver, muscle, pancreas and brain. And their potentials as the mTOR related pharmacological targets will be also discussed.
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spelling pubmed-60737662018-08-13 Role of mTOR in Glucose and Lipid Metabolism Mao, Zhuo Zhang, Weizhen Int J Mol Sci Review The mammalian target of rapamycin, mTOR is the master regulator of a cell’s growth and metabolic state in response to nutrients, growth factors and many extracellular cues. Its dysregulation leads to a number of metabolic pathological conditions, including obesity and type 2 diabetes. Here, we review recent findings on the role of mTOR in major metabolic organs, such as adipose tissues, liver, muscle, pancreas and brain. And their potentials as the mTOR related pharmacological targets will be also discussed. MDPI 2018-07-13 /pmc/articles/PMC6073766/ /pubmed/30011848 http://dx.doi.org/10.3390/ijms19072043 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mao, Zhuo
Zhang, Weizhen
Role of mTOR in Glucose and Lipid Metabolism
title Role of mTOR in Glucose and Lipid Metabolism
title_full Role of mTOR in Glucose and Lipid Metabolism
title_fullStr Role of mTOR in Glucose and Lipid Metabolism
title_full_unstemmed Role of mTOR in Glucose and Lipid Metabolism
title_short Role of mTOR in Glucose and Lipid Metabolism
title_sort role of mtor in glucose and lipid metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073766/
https://www.ncbi.nlm.nih.gov/pubmed/30011848
http://dx.doi.org/10.3390/ijms19072043
work_keys_str_mv AT maozhuo roleofmtoringlucoseandlipidmetabolism
AT zhangweizhen roleofmtoringlucoseandlipidmetabolism

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