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Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria

LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders. LIGHT induces the expres...

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Autores principales: Kasperska-Zając, Alicja, Damasiewicz-Bodzek, Aleksandra, Grzanka, Ryszard, Skrzypulec-Frankel, Agnieszka, Bieniek, Katarzyna, Sikora-Żydek, Agnieszka, Jochem, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073820/
https://www.ncbi.nlm.nih.gov/pubmed/29952668
http://dx.doi.org/10.1177/2058738418784431
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author Kasperska-Zając, Alicja
Damasiewicz-Bodzek, Aleksandra
Grzanka, Ryszard
Skrzypulec-Frankel, Agnieszka
Bieniek, Katarzyna
Sikora-Żydek, Agnieszka
Jochem, Jerzy
author_facet Kasperska-Zając, Alicja
Damasiewicz-Bodzek, Aleksandra
Grzanka, Ryszard
Skrzypulec-Frankel, Agnieszka
Bieniek, Katarzyna
Sikora-Żydek, Agnieszka
Jochem, Jerzy
author_sort Kasperska-Zając, Alicja
collection PubMed
description LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders. LIGHT induces the expression of interleukin-8 (IL-8), which is up-regulated in chronic spontaneous urticaria (CSU). To determine circulating soluble LIGHT concentration and its relationship with IL-8 concentration in patients with CSU. Concentrations of LIGHT, IL-8, and C-reactive protein (CRP) were determined in plasma or serum of CSU patients by an enzyme-linked immunosorbent assay. LIGHT plasma concentration was significantly higher in moderate–severe CSU patients as compared with the healthy subjects, but not with mild CSU patients. There were significant correlations between increased LIGHT and IL-8 concentrations, but not with increased CRP in CSU patients. Enhanced plasma concentrations of soluble LIGHT and its association with IL-8 concentration suggest the role of LIGHT in systemic inflammatory activation in CSU patients. We hypothesize that LIGHT-mediated immune–inflammatory response plays a role in severe phenotypes of the disease.
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spelling pubmed-60738202018-08-06 Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria Kasperska-Zając, Alicja Damasiewicz-Bodzek, Aleksandra Grzanka, Ryszard Skrzypulec-Frankel, Agnieszka Bieniek, Katarzyna Sikora-Żydek, Agnieszka Jochem, Jerzy Int J Immunopathol Pharmacol Letter to the Editor LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders. LIGHT induces the expression of interleukin-8 (IL-8), which is up-regulated in chronic spontaneous urticaria (CSU). To determine circulating soluble LIGHT concentration and its relationship with IL-8 concentration in patients with CSU. Concentrations of LIGHT, IL-8, and C-reactive protein (CRP) were determined in plasma or serum of CSU patients by an enzyme-linked immunosorbent assay. LIGHT plasma concentration was significantly higher in moderate–severe CSU patients as compared with the healthy subjects, but not with mild CSU patients. There were significant correlations between increased LIGHT and IL-8 concentrations, but not with increased CRP in CSU patients. Enhanced plasma concentrations of soluble LIGHT and its association with IL-8 concentration suggest the role of LIGHT in systemic inflammatory activation in CSU patients. We hypothesize that LIGHT-mediated immune–inflammatory response plays a role in severe phenotypes of the disease. SAGE Publications 2018-06-28 /pmc/articles/PMC6073820/ /pubmed/29952668 http://dx.doi.org/10.1177/2058738418784431 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Letter to the Editor
Kasperska-Zając, Alicja
Damasiewicz-Bodzek, Aleksandra
Grzanka, Ryszard
Skrzypulec-Frankel, Agnieszka
Bieniek, Katarzyna
Sikora-Żydek, Agnieszka
Jochem, Jerzy
Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria
title Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria
title_full Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria
title_fullStr Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria
title_full_unstemmed Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria
title_short Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria
title_sort circulating soluble light/tnfsf14 is increased and associated with il-8 concentration in chronic spontaneous urticaria
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073820/
https://www.ncbi.nlm.nih.gov/pubmed/29952668
http://dx.doi.org/10.1177/2058738418784431
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