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Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting

The first cases of human melioidosis were described in Vietnam in the 1920s, almost a century ago. It was in Vietnam in the thirties that the saprophytic nature of B. pseudomallei was first recognized. Although a significant number of French and U.S. soldiers acquired the disease during the Vietnam...

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Autores principales: Trinh, Trung T., Nguyen, Linh D. N., Nguyen, Trung V., Tran, Chuong X., Le, An V., Nguyen, Hao V., Assig, Karoline, Lichtenegger, Sabine, Wagner, Gabriel E., Do, Cuong D., Steinmetz, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073866/
https://www.ncbi.nlm.nih.gov/pubmed/30274435
http://dx.doi.org/10.3390/tropicalmed3020039
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author Trinh, Trung T.
Nguyen, Linh D. N.
Nguyen, Trung V.
Tran, Chuong X.
Le, An V.
Nguyen, Hao V.
Assig, Karoline
Lichtenegger, Sabine
Wagner, Gabriel E.
Do, Cuong D.
Steinmetz, Ivo
author_facet Trinh, Trung T.
Nguyen, Linh D. N.
Nguyen, Trung V.
Tran, Chuong X.
Le, An V.
Nguyen, Hao V.
Assig, Karoline
Lichtenegger, Sabine
Wagner, Gabriel E.
Do, Cuong D.
Steinmetz, Ivo
author_sort Trinh, Trung T.
collection PubMed
description The first cases of human melioidosis were described in Vietnam in the 1920s, almost a century ago. It was in Vietnam in the thirties that the saprophytic nature of B. pseudomallei was first recognized. Although a significant number of French and U.S. soldiers acquired the disease during the Vietnam wars, indigenous cases in the Vietnamese population were only sporadically reported over many decades. After reunification in 1975, only two retrospective studies reported relatively small numbers of indigenous cases from single tertiary care hospitals located in the biggest cities in the South and the North, respectively. Studies from provincial hospitals throughout the country were missing until the Research Network on Melioidosis and Burkholderia pseudomallei (RENOMAB) project started in 2014. From then on seminars, workshops, and national scientific conferences on melioidosis have been conducted to raise awareness among physicians and clinical laboratory staff. This led to the recognition of a significant number of cases in at least 36 hospitals in 26 provinces and cities throughout Vietnam. Although a widespread distribution of melioidosis has now been documented, there are still challenges to understand the true epidemiology of the disease. Establishment of national guidelines for diagnosis, management, and reporting of the disease together with more investigations on animal melioidosis, genomic diversity of B. pseudomallei and its environmental distribution are required.
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spelling pubmed-60738662018-09-24 Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting Trinh, Trung T. Nguyen, Linh D. N. Nguyen, Trung V. Tran, Chuong X. Le, An V. Nguyen, Hao V. Assig, Karoline Lichtenegger, Sabine Wagner, Gabriel E. Do, Cuong D. Steinmetz, Ivo Trop Med Infect Dis Review The first cases of human melioidosis were described in Vietnam in the 1920s, almost a century ago. It was in Vietnam in the thirties that the saprophytic nature of B. pseudomallei was first recognized. Although a significant number of French and U.S. soldiers acquired the disease during the Vietnam wars, indigenous cases in the Vietnamese population were only sporadically reported over many decades. After reunification in 1975, only two retrospective studies reported relatively small numbers of indigenous cases from single tertiary care hospitals located in the biggest cities in the South and the North, respectively. Studies from provincial hospitals throughout the country were missing until the Research Network on Melioidosis and Burkholderia pseudomallei (RENOMAB) project started in 2014. From then on seminars, workshops, and national scientific conferences on melioidosis have been conducted to raise awareness among physicians and clinical laboratory staff. This led to the recognition of a significant number of cases in at least 36 hospitals in 26 provinces and cities throughout Vietnam. Although a widespread distribution of melioidosis has now been documented, there are still challenges to understand the true epidemiology of the disease. Establishment of national guidelines for diagnosis, management, and reporting of the disease together with more investigations on animal melioidosis, genomic diversity of B. pseudomallei and its environmental distribution are required. MDPI 2018-04-09 /pmc/articles/PMC6073866/ /pubmed/30274435 http://dx.doi.org/10.3390/tropicalmed3020039 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Trinh, Trung T.
Nguyen, Linh D. N.
Nguyen, Trung V.
Tran, Chuong X.
Le, An V.
Nguyen, Hao V.
Assig, Karoline
Lichtenegger, Sabine
Wagner, Gabriel E.
Do, Cuong D.
Steinmetz, Ivo
Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting
title Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting
title_full Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting
title_fullStr Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting
title_full_unstemmed Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting
title_short Melioidosis in Vietnam: Recently Improved Recognition but still an Uncertain Disease Burden after Almost a Century of Reporting
title_sort melioidosis in vietnam: recently improved recognition but still an uncertain disease burden after almost a century of reporting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073866/
https://www.ncbi.nlm.nih.gov/pubmed/30274435
http://dx.doi.org/10.3390/tropicalmed3020039
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