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Anti-Correlation between the Dynamics of the Active Site Loop and C-Terminal Tail in Relation to the Homodimer Asymmetry of the Mouse Erythroid 5-Aminolevulinate Synthase

Biosynthesis of heme represents a complex process that involves multiple stages controlled by different enzymes. The first of these proteins is a pyridoxal 5′-phosphate (PLP)-dependent homodimeric enzyme, 5-aminolevulinate synthase (ALAS), that catalyzes the rate-limiting step in heme biosynthesis,...

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Detalles Bibliográficos
Autores principales:	Na, Insung, Catena, Dominique, Kong, Min J., Ferreira, Gloria C., Uversky, Vladimir N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073955/ https://www.ncbi.nlm.nih.gov/pubmed/29958424 http://dx.doi.org/10.3390/ijms19071899

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