BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice

β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is required for the production of β-amyloid (Aβ), one of the major pathogenic molecules of Alzheimer’s disease (AD), and is therefore being actively pursued as a drug target for AD. Adult hippocampal neurogenesis (AHN) is a lifelong process...

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Detalles Bibliográficos
Autores principales: Chatila, Zena K., Kim, Eunhee, Berlé, Clara, Bylykbashi, Enjana, Rompala, Alexander, Oram, Mary K., Gupta, Drew, Kwak, Sang Su, Kim, Young Hye, Kim, Doo Yeon, Choi, Se Hoon, Tanzi, Rudolph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073981/
https://www.ncbi.nlm.nih.gov/pubmed/30079376
http://dx.doi.org/10.1523/ENEURO.0067-18.2018

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