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Prognostic factors for epilepsy following first febrile seizure in Saudi children

BACKGROUND: Febrile seizure is the most common convulsive event during childhood, but it is generally considered benign. OBJECTIVES: To estimate the rate of epilepsy after first presentation of febrile seizure and to describe factors that can predispose children to have subsequent epilepsy after the...

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Autores principales: Almojali, Abdullah I., Ahmed, Anwar E., Bagha, Muhammed Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074123/
https://www.ncbi.nlm.nih.gov/pubmed/29229893
http://dx.doi.org/10.5144/0256-4947.2017.449
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author Almojali, Abdullah I.
Ahmed, Anwar E.
Bagha, Muhammed Y.
author_facet Almojali, Abdullah I.
Ahmed, Anwar E.
Bagha, Muhammed Y.
author_sort Almojali, Abdullah I.
collection PubMed
description BACKGROUND: Febrile seizure is the most common convulsive event during childhood, but it is generally considered benign. OBJECTIVES: To estimate the rate of epilepsy after first presentation of febrile seizure and to describe factors that can predispose children to have subsequent epilepsy after their first febrile seizure. DESIGN: Retrospective chart review. SETTING: A tertiary care center in Riyadh. PATIENTS AND METHODS: All children whose first febrile seizure developed between 2009–2012, and who were admitted to the pediatric wards. MAIN OUTCOME MEASURES: The rate of epilepsy and prognostic factors for epilepsy following first febrile seizure. RESULTS: Of 109 febrile seizure patients, 6 (5.5%, 95% CI: 2.1% – 11.6%) were diagnosed with subsequent epilepsy 5 to 46 months after their first febrile seizure. The risk of having subsequent epilepsy was higher in children who were convulsing at a low-grade fever during their first febrile convulsion (P=.02). Moreover, delayed vaccination status (P=.03), prolonged duration of the first convulsion (P=.04), frequent febrile seizures (P=.01), and fever without documented infection (P=.03) during the first febrile convulsion were associated with epilepsy. CONCLUSION: The rate of epilepsy following first febrile seizure in Saudi children is within the range of values reported in different populations. Although most childhood febrile seizures are self-limiting, careful observation is needed, particularly for children who exhibit factors associated with epilepsy. LIMITATIONS: Conducted at a single center in Saudi Arabia, which may limit generalizability.
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spelling pubmed-60741232018-09-21 Prognostic factors for epilepsy following first febrile seizure in Saudi children Almojali, Abdullah I. Ahmed, Anwar E. Bagha, Muhammed Y. Ann Saudi Med Original Article BACKGROUND: Febrile seizure is the most common convulsive event during childhood, but it is generally considered benign. OBJECTIVES: To estimate the rate of epilepsy after first presentation of febrile seizure and to describe factors that can predispose children to have subsequent epilepsy after their first febrile seizure. DESIGN: Retrospective chart review. SETTING: A tertiary care center in Riyadh. PATIENTS AND METHODS: All children whose first febrile seizure developed between 2009–2012, and who were admitted to the pediatric wards. MAIN OUTCOME MEASURES: The rate of epilepsy and prognostic factors for epilepsy following first febrile seizure. RESULTS: Of 109 febrile seizure patients, 6 (5.5%, 95% CI: 2.1% – 11.6%) were diagnosed with subsequent epilepsy 5 to 46 months after their first febrile seizure. The risk of having subsequent epilepsy was higher in children who were convulsing at a low-grade fever during their first febrile convulsion (P=.02). Moreover, delayed vaccination status (P=.03), prolonged duration of the first convulsion (P=.04), frequent febrile seizures (P=.01), and fever without documented infection (P=.03) during the first febrile convulsion were associated with epilepsy. CONCLUSION: The rate of epilepsy following first febrile seizure in Saudi children is within the range of values reported in different populations. Although most childhood febrile seizures are self-limiting, careful observation is needed, particularly for children who exhibit factors associated with epilepsy. LIMITATIONS: Conducted at a single center in Saudi Arabia, which may limit generalizability. King Faisal Specialist Hospital and Research Centre 2017 /pmc/articles/PMC6074123/ /pubmed/29229893 http://dx.doi.org/10.5144/0256-4947.2017.449 Text en Copyright © 2017, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Almojali, Abdullah I.
Ahmed, Anwar E.
Bagha, Muhammed Y.
Prognostic factors for epilepsy following first febrile seizure in Saudi children
title Prognostic factors for epilepsy following first febrile seizure in Saudi children
title_full Prognostic factors for epilepsy following first febrile seizure in Saudi children
title_fullStr Prognostic factors for epilepsy following first febrile seizure in Saudi children
title_full_unstemmed Prognostic factors for epilepsy following first febrile seizure in Saudi children
title_short Prognostic factors for epilepsy following first febrile seizure in Saudi children
title_sort prognostic factors for epilepsy following first febrile seizure in saudi children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074123/
https://www.ncbi.nlm.nih.gov/pubmed/29229893
http://dx.doi.org/10.5144/0256-4947.2017.449
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