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Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome
BACKGROUND: Status epilepticus (SE) is a common, life-threatening condition. Multiple factors are used to predict its outcome and evaluate its risks, and there have been only a few studies in Saudi Arabia. OBJECTIVES: Investigate predictors of SE outcome. DESIGN: Retrospective chart review study. SE...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
King Faisal Specialist Hospital and Research Centre
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074125/ https://www.ncbi.nlm.nih.gov/pubmed/29229894 http://dx.doi.org/10.5144/0256-4947.2017.455 |
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author | Hommady, Raid Harb Alrifai, Muhammad Talal Mubayrik, Osama Khaled Alayed, Ruba Salem Alsemari, Muhannad Abdulrahman Arumayyan, Ahmed Altuwaijri, Waleed Baarmah, Duaa |
author_facet | Hommady, Raid Harb Alrifai, Muhammad Talal Mubayrik, Osama Khaled Alayed, Ruba Salem Alsemari, Muhannad Abdulrahman Arumayyan, Ahmed Altuwaijri, Waleed Baarmah, Duaa |
author_sort | Hommady, Raid Harb |
collection | PubMed |
description | BACKGROUND: Status epilepticus (SE) is a common, life-threatening condition. Multiple factors are used to predict its outcome and evaluate its risks, and there have been only a few studies in Saudi Arabia. OBJECTIVES: Investigate predictors of SE outcome. DESIGN: Retrospective chart review study. SETTING: Tertiary center, Riyadh. PATIENTS AND METHODS: We reviewed all pediatric cases (age 14 years or younger) of SE admitted between January 2005 and December 2015, collecting data on age, sex, date of birth, developmental status, pre-existing neurological diseases, SE etiology, Glasgow Outcome Scale (GOS) scores, and electroencephalogram (EEG) findings. The outcome was categorized as poor based on any decrease in baseline GOS score or moderate-to-severe developmental delay in young children; otherwise outcome was considered good. MAIN OUTCOME MEASURE: Outcome of SE. RESULTS: One hundred and sixteen patients (54% boys) with ages from 1 month to 10 years were included in the analysis. Fifty-five (47.4%) had a poor outcome. The overall mortality rate related to SE was 2.6%. Four patients had an SE duration of more than 24 hours. Univariate and multivariate analysis revealed that poor outcome was related to symptomatic SE etiology and a history of epilepsy. Age, sex, SE duration, and EEG findings were not predictors of poor outcome. CONCLUSION: Pediatric status epilepticus is highly associated with neurological morbidity. The main predictor of outcome is underlying symptomatic etiology of SE and to a lesser degree the presence of a history of epilepsy. Duration does not seem to play a major role. LIMITATIONS: The main limitation is the retrospective chart review nature of the study with possible bias. |
format | Online Article Text |
id | pubmed-6074125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | King Faisal Specialist Hospital and Research Centre |
record_format | MEDLINE/PubMed |
spelling | pubmed-60741252018-09-21 Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome Hommady, Raid Harb Alrifai, Muhammad Talal Mubayrik, Osama Khaled Alayed, Ruba Salem Alsemari, Muhannad Abdulrahman Arumayyan, Ahmed Altuwaijri, Waleed Baarmah, Duaa Ann Saudi Med Original Article BACKGROUND: Status epilepticus (SE) is a common, life-threatening condition. Multiple factors are used to predict its outcome and evaluate its risks, and there have been only a few studies in Saudi Arabia. OBJECTIVES: Investigate predictors of SE outcome. DESIGN: Retrospective chart review study. SETTING: Tertiary center, Riyadh. PATIENTS AND METHODS: We reviewed all pediatric cases (age 14 years or younger) of SE admitted between January 2005 and December 2015, collecting data on age, sex, date of birth, developmental status, pre-existing neurological diseases, SE etiology, Glasgow Outcome Scale (GOS) scores, and electroencephalogram (EEG) findings. The outcome was categorized as poor based on any decrease in baseline GOS score or moderate-to-severe developmental delay in young children; otherwise outcome was considered good. MAIN OUTCOME MEASURE: Outcome of SE. RESULTS: One hundred and sixteen patients (54% boys) with ages from 1 month to 10 years were included in the analysis. Fifty-five (47.4%) had a poor outcome. The overall mortality rate related to SE was 2.6%. Four patients had an SE duration of more than 24 hours. Univariate and multivariate analysis revealed that poor outcome was related to symptomatic SE etiology and a history of epilepsy. Age, sex, SE duration, and EEG findings were not predictors of poor outcome. CONCLUSION: Pediatric status epilepticus is highly associated with neurological morbidity. The main predictor of outcome is underlying symptomatic etiology of SE and to a lesser degree the presence of a history of epilepsy. Duration does not seem to play a major role. LIMITATIONS: The main limitation is the retrospective chart review nature of the study with possible bias. King Faisal Specialist Hospital and Research Centre 2017 /pmc/articles/PMC6074125/ /pubmed/29229894 http://dx.doi.org/10.5144/0256-4947.2017.455 Text en Copyright © 2017, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Hommady, Raid Harb Alrifai, Muhammad Talal Mubayrik, Osama Khaled Alayed, Ruba Salem Alsemari, Muhannad Abdulrahman Arumayyan, Ahmed Altuwaijri, Waleed Baarmah, Duaa Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome |
title | Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome |
title_full | Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome |
title_fullStr | Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome |
title_full_unstemmed | Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome |
title_short | Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome |
title_sort | retrospective review of pediatric status epilepticus in 116 saudi patients: predictors of outcome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074125/ https://www.ncbi.nlm.nih.gov/pubmed/29229894 http://dx.doi.org/10.5144/0256-4947.2017.455 |
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