Cargando…

Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices

BACKGROUND AND OBJECTIVES: Animal studies suggest that undernutrition and low body weight are associated with low kisspeptin expression and vice versa. This led us to hypothesize that obese and overweight individuals might have significant differences in kisspeptin levels compared with normal-weight...

Descripción completa

Detalles Bibliográficos
Autores principales: Rafique, Nazish, Latif, Rabia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074126/
https://www.ncbi.nlm.nih.gov/pubmed/26336023
http://dx.doi.org/10.5144/0256-4947.2015.157
_version_ 1783344337123278848
author Rafique, Nazish
Latif, Rabia
author_facet Rafique, Nazish
Latif, Rabia
author_sort Rafique, Nazish
collection PubMed
description BACKGROUND AND OBJECTIVES: Animal studies suggest that undernutrition and low body weight are associated with low kisspeptin expression and vice versa. This led us to hypothesize that obese and overweight individuals might have significant differences in kisspeptin levels compared with normal-weight individuals. DESIGN AND SETTINGS: A prospective cohort study of 1-year duration involving young Saudi female students in the University of Dammam. SUBJECTS AND METHODS: Young Saudi females studying in a Saudi university were divided into 2 groups: normal weight with a body mass index (BMI)=18.5–24.99 and overweight/obese with a BMI ≥25. Serum kisspeptin levels were measured by enzyme-linked immunosorbent assay in early follicular, pre-ovulatory, and luteal phases, and anthropometric parameters were recorded. RESULTS: Mean serum kisspeptin levels in the overweight/obese group (follicular phase: 266.88 [45.53], pre-ovulatory phase: 477.12 [21.18], and luteal phase: 735.13 [52.59]) did not differ significantly compared with the normal-weight group (follicular phase: 259.82 [20.50], pre-ovulatory phase: 448.36 [24.58], and luteal phase 708.18 [49.47]) in any of the menstrual phase. In any of the menstrual phase, kisspeptin levels were not found to be correlated with any of the anthropometric variable in any group. CONCLUSION: Serum kisspeptin levels in overweight and obese young females may not differ significantly compared with normal-weight females, and there may not be any correlation between serum kisspeptin and anthropometric indices.
format Online
Article
Text
id pubmed-6074126
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher King Faisal Specialist Hospital and Research Centre
record_format MEDLINE/PubMed
spelling pubmed-60741262018-09-21 Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices Rafique, Nazish Latif, Rabia Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: Animal studies suggest that undernutrition and low body weight are associated with low kisspeptin expression and vice versa. This led us to hypothesize that obese and overweight individuals might have significant differences in kisspeptin levels compared with normal-weight individuals. DESIGN AND SETTINGS: A prospective cohort study of 1-year duration involving young Saudi female students in the University of Dammam. SUBJECTS AND METHODS: Young Saudi females studying in a Saudi university were divided into 2 groups: normal weight with a body mass index (BMI)=18.5–24.99 and overweight/obese with a BMI ≥25. Serum kisspeptin levels were measured by enzyme-linked immunosorbent assay in early follicular, pre-ovulatory, and luteal phases, and anthropometric parameters were recorded. RESULTS: Mean serum kisspeptin levels in the overweight/obese group (follicular phase: 266.88 [45.53], pre-ovulatory phase: 477.12 [21.18], and luteal phase: 735.13 [52.59]) did not differ significantly compared with the normal-weight group (follicular phase: 259.82 [20.50], pre-ovulatory phase: 448.36 [24.58], and luteal phase 708.18 [49.47]) in any of the menstrual phase. In any of the menstrual phase, kisspeptin levels were not found to be correlated with any of the anthropometric variable in any group. CONCLUSION: Serum kisspeptin levels in overweight and obese young females may not differ significantly compared with normal-weight females, and there may not be any correlation between serum kisspeptin and anthropometric indices. King Faisal Specialist Hospital and Research Centre 2015 /pmc/articles/PMC6074126/ /pubmed/26336023 http://dx.doi.org/10.5144/0256-4947.2015.157 Text en Copyright © 2015, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Rafique, Nazish
Latif, Rabia
Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices
title Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices
title_full Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices
title_fullStr Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices
title_full_unstemmed Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices
title_short Serum kisspeptin levels in normal and overweight Saudi females and its relation with anthropometric indices
title_sort serum kisspeptin levels in normal and overweight saudi females and its relation with anthropometric indices
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074126/
https://www.ncbi.nlm.nih.gov/pubmed/26336023
http://dx.doi.org/10.5144/0256-4947.2015.157
work_keys_str_mv AT rafiquenazish serumkisspeptinlevelsinnormalandoverweightsaudifemalesanditsrelationwithanthropometricindices
AT latifrabia serumkisspeptinlevelsinnormalandoverweightsaudifemalesanditsrelationwithanthropometricindices