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Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study

BACKGROUND AND OBJECTIVES: Chronic rhinosinusitis (CRS) is a commonly diagnosed disease that has a significant impact on a child’s quality of life. However, no useful biomarker is available to identify antibiotic-responsive CRS. We determined the significance of eosinophil-related markers and total...

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Autores principales: Shin, Youn Ho, Kim, Hwan Soo, Lee, Eu Kyoung, Kim, Young Joo, Lee, Hyun-Seung, Jang, Pil-Sang, Kim, Young-Hoon, Chun, Yoon Hong, Yoon, Jong-seo, Kim, Hyun Hee, Koh, Young-Yull, Kim, Jin Tack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074215/
https://www.ncbi.nlm.nih.gov/pubmed/26497712
http://dx.doi.org/10.5144/0256-4947.2015.312
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author Shin, Youn Ho
Kim, Hwan Soo
Lee, Eu Kyoung
Kim, Young Joo
Lee, Hyun-Seung
Jang, Pil-Sang
Kim, Young-Hoon
Chun, Yoon Hong
Yoon, Jong-seo
Kim, Hyun Hee
Koh, Young-Yull
Kim, Jin Tack
author_facet Shin, Youn Ho
Kim, Hwan Soo
Lee, Eu Kyoung
Kim, Young Joo
Lee, Hyun-Seung
Jang, Pil-Sang
Kim, Young-Hoon
Chun, Yoon Hong
Yoon, Jong-seo
Kim, Hyun Hee
Koh, Young-Yull
Kim, Jin Tack
author_sort Shin, Youn Ho
collection PubMed
description BACKGROUND AND OBJECTIVES: Chronic rhinosinusitis (CRS) is a commonly diagnosed disease that has a significant impact on a child’s quality of life. However, no useful biomarker is available to identify antibiotic-responsive CRS. We determined the significance of eosinophil-related markers and total IgE levels in childhood CRS with regard to antibiotic response. DESIGN AND SETTING: This was a case-control study of patients admitted to Uijeongbu St. Mary’s Hospital between November 2010 and November 2011 and diagnosed with CRS. PATIENTS AND METHODS: In this analytical cross-sectional study, we identified children whose symptoms and radiologic abnormalities did not resolve after 12 weeks despite appropriate antibiotics (non-responder CRS group), children whose symptoms and radiologic abnormalities resolved after 12 weeks with appropriate antibiotics (responder CRS group), and healthy controls selected from clinic patients. Skin prick tests were performed along with serum total IgE, total eosinophil count (TEC), serum eosinophil cationic protein (ECP) level, and ImmunoCAP analysis for common allergens. RESULTS: This study included 36 responders, 22 nonresponders and 22 healthy controls. The prevalence of allergic diseases, atopy, and a family history of allergic diseases were significantly higher in the non-responder group than in the responder and control groups. TEC, ECP, and total IgE levels were significantly higher in the non-responder group than in the responder and control groups (all P<.05). Multiple linear regression analysis showed that no response to appropriate antibiotics and TEC was positively associated with ECP concentration. CONCLUSION: These findings suggest that there is a high prevalence of allergic diseases in the non-responder group, that the TEC and ECP levels in the non-responder group are significantly higher than those in the responder group and controls, and that no response to antibiotics may be due to eosinophilic inflammation. The measurement of serum ECP may be useful in monitoring the progress of childhood CRS with regard to antibiotic response.
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spelling pubmed-60742152018-09-21 Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study Shin, Youn Ho Kim, Hwan Soo Lee, Eu Kyoung Kim, Young Joo Lee, Hyun-Seung Jang, Pil-Sang Kim, Young-Hoon Chun, Yoon Hong Yoon, Jong-seo Kim, Hyun Hee Koh, Young-Yull Kim, Jin Tack Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: Chronic rhinosinusitis (CRS) is a commonly diagnosed disease that has a significant impact on a child’s quality of life. However, no useful biomarker is available to identify antibiotic-responsive CRS. We determined the significance of eosinophil-related markers and total IgE levels in childhood CRS with regard to antibiotic response. DESIGN AND SETTING: This was a case-control study of patients admitted to Uijeongbu St. Mary’s Hospital between November 2010 and November 2011 and diagnosed with CRS. PATIENTS AND METHODS: In this analytical cross-sectional study, we identified children whose symptoms and radiologic abnormalities did not resolve after 12 weeks despite appropriate antibiotics (non-responder CRS group), children whose symptoms and radiologic abnormalities resolved after 12 weeks with appropriate antibiotics (responder CRS group), and healthy controls selected from clinic patients. Skin prick tests were performed along with serum total IgE, total eosinophil count (TEC), serum eosinophil cationic protein (ECP) level, and ImmunoCAP analysis for common allergens. RESULTS: This study included 36 responders, 22 nonresponders and 22 healthy controls. The prevalence of allergic diseases, atopy, and a family history of allergic diseases were significantly higher in the non-responder group than in the responder and control groups. TEC, ECP, and total IgE levels were significantly higher in the non-responder group than in the responder and control groups (all P<.05). Multiple linear regression analysis showed that no response to appropriate antibiotics and TEC was positively associated with ECP concentration. CONCLUSION: These findings suggest that there is a high prevalence of allergic diseases in the non-responder group, that the TEC and ECP levels in the non-responder group are significantly higher than those in the responder group and controls, and that no response to antibiotics may be due to eosinophilic inflammation. The measurement of serum ECP may be useful in monitoring the progress of childhood CRS with regard to antibiotic response. King Faisal Specialist Hospital and Research Centre 2015 /pmc/articles/PMC6074215/ /pubmed/26497712 http://dx.doi.org/10.5144/0256-4947.2015.312 Text en Copyright © 2015, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Shin, Youn Ho
Kim, Hwan Soo
Lee, Eu Kyoung
Kim, Young Joo
Lee, Hyun-Seung
Jang, Pil-Sang
Kim, Young-Hoon
Chun, Yoon Hong
Yoon, Jong-seo
Kim, Hyun Hee
Koh, Young-Yull
Kim, Jin Tack
Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study
title Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study
title_full Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study
title_fullStr Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study
title_full_unstemmed Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study
title_short Eosinophil related markers and total immunoglobulin E as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study
title_sort eosinophil related markers and total immunoglobulin e as a predictive marker for antibiotics response in chronic rhinosinusitis: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074215/
https://www.ncbi.nlm.nih.gov/pubmed/26497712
http://dx.doi.org/10.5144/0256-4947.2015.312
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