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Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding

BACKGROUND AND OBJECTIVES: We compared endometrial sampling by pipelle endometrial curette with conventional dilatation and curettage (D&C) in patients with abnormal uterine bleeding. METHODS: Endometrial sampling with pipelle curette was performed on 100 patients followed by formal D&C. Sam...

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Autores principales: Fakhar, Shazia, Saeed, Gulshan, Khan, Amir Hussain, Alam, Ali Yawar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074409/
https://www.ncbi.nlm.nih.gov/pubmed/18500186
http://dx.doi.org/10.5144/0256-4947.2008.188
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author Fakhar, Shazia
Saeed, Gulshan
Khan, Amir Hussain
Alam, Ali Yawar
author_facet Fakhar, Shazia
Saeed, Gulshan
Khan, Amir Hussain
Alam, Ali Yawar
author_sort Fakhar, Shazia
collection PubMed
description BACKGROUND AND OBJECTIVES: We compared endometrial sampling by pipelle endometrial curette with conventional dilatation and curettage (D&C) in patients with abnormal uterine bleeding. METHODS: Endometrial sampling with pipelle curette was performed on 100 patients followed by formal D&C. Samples were labeled as A and B, respectively, and sent to a histopathologist who was blinded as to the method of sampling. The histopathology reports of both samples were compared, taking D&C as the gold standard. RESULTS: An adequate sample was obtained in 98% of cases by pipelle and in 100% of cases by D&C. Pipelle had a sensitivity, specificity, positive predictive value and negative predictive value of 100% for diagnosing endometrial carcinoma, hyperplasia and secretory endometrium. Pipelle also had high diagnostic sensitivity, specificity and negative predictive value (100%, 98% and 100%, respectively) for hyperplasia with atypia, and low sensitivity (57%) and positive predictive value (57%), but high specificity (97%) and negative predictive value (97%) for endometritis. Similarly, for proliferative endometrium, the pipelle technique had values of 94% and 93% for sensitivity and specificity, respectively. Both samples labeled as inadequate for histology by pipelle were polyps on the D&C report. Difficult endotracheal intubation was encountered in two cases of D&C. No other complications of the procedure were observed. CONCLUSION: The pipelle is a safe device for getting an adequate endometrial sample for histology, with a high sensitivity and specificity for detection of hyperplasia and malignancy.
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spelling pubmed-60744092018-09-21 Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding Fakhar, Shazia Saeed, Gulshan Khan, Amir Hussain Alam, Ali Yawar Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: We compared endometrial sampling by pipelle endometrial curette with conventional dilatation and curettage (D&C) in patients with abnormal uterine bleeding. METHODS: Endometrial sampling with pipelle curette was performed on 100 patients followed by formal D&C. Samples were labeled as A and B, respectively, and sent to a histopathologist who was blinded as to the method of sampling. The histopathology reports of both samples were compared, taking D&C as the gold standard. RESULTS: An adequate sample was obtained in 98% of cases by pipelle and in 100% of cases by D&C. Pipelle had a sensitivity, specificity, positive predictive value and negative predictive value of 100% for diagnosing endometrial carcinoma, hyperplasia and secretory endometrium. Pipelle also had high diagnostic sensitivity, specificity and negative predictive value (100%, 98% and 100%, respectively) for hyperplasia with atypia, and low sensitivity (57%) and positive predictive value (57%), but high specificity (97%) and negative predictive value (97%) for endometritis. Similarly, for proliferative endometrium, the pipelle technique had values of 94% and 93% for sensitivity and specificity, respectively. Both samples labeled as inadequate for histology by pipelle were polyps on the D&C report. Difficult endotracheal intubation was encountered in two cases of D&C. No other complications of the procedure were observed. CONCLUSION: The pipelle is a safe device for getting an adequate endometrial sample for histology, with a high sensitivity and specificity for detection of hyperplasia and malignancy. King Faisal Specialist Hospital and Research Centre 2008 /pmc/articles/PMC6074409/ /pubmed/18500186 http://dx.doi.org/10.5144/0256-4947.2008.188 Text en Copyright © 2008, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Fakhar, Shazia
Saeed, Gulshan
Khan, Amir Hussain
Alam, Ali Yawar
Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding
title Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding
title_full Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding
title_fullStr Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding
title_full_unstemmed Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding
title_short Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding
title_sort validity of pipelle endometrial sampling in patients with abnormal uterine bleeding
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074409/
https://www.ncbi.nlm.nih.gov/pubmed/18500186
http://dx.doi.org/10.5144/0256-4947.2008.188
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