Rotavirus infection in Saudi Arabia

BACKGROUND: Human rotavirus, an important causative agent of severe gastroenteritis in infants and young children worldwide, leads to high morbidity in both developing and developed countries, including Saudi Arabia, and high mortality in developing countries. Effective control depends upon an accur...

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Autores principales: Kheyami, Ali M., Cunliffe, Nigel A., Hart, C. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074438/
https://www.ncbi.nlm.nih.gov/pubmed/16861867
http://dx.doi.org/10.5144/0256-4947.2006.184
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author Kheyami, Ali M.
Cunliffe, Nigel A.
Hart, C. Anthony
author_facet Kheyami, Ali M.
Cunliffe, Nigel A.
Hart, C. Anthony
author_sort Kheyami, Ali M.
collection PubMed
description BACKGROUND: Human rotavirus, an important causative agent of severe gastroenteritis in infants and young children worldwide, leads to high morbidity in both developing and developed countries, including Saudi Arabia, and high mortality in developing countries. Effective control depends upon an accurate understanding of disease burden and the relative importance of circulating serotypes. METHODS: We examined the epidemiology and disease burden of rotavirus in Saudi Arabia through a review of 22 published studies of rotavirus and the aetiology of diarrhoea carried out from 1982 to 2003. RESULTS: The prevalence of rotavirus infection ranged between 10% to 46% with a median of 30%. Most cases were among children less than 2 years of age, and particularly in the first year of life. There were significant differences in seasonality within Saudi Arabia, with increased infection during winter in some cities and during summer in others. G1 was the predominant serotype followed by G4, G3 and G2, in 4 studies where strains had been G-typed. The prevalence of nontypeable strains ranged from 11.0% to 31.3%. No data were available on P types. Results of electropherotyping in 4 studies revealed that the long electropherotype was predominant. CONCLUSION: Rotavirus is an important cause of severe diarrhoea in Saudi children. However, the available data on rotavirus strains in circulation are limited and there is an urgent need for up-to-date and comprehensive studies to evaluate rotavirus strains in circulation and identify unusual types that could be incorporated into future vaccines.
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spelling pubmed-60744382018-09-21 Rotavirus infection in Saudi Arabia Kheyami, Ali M. Cunliffe, Nigel A. Hart, C. Anthony Ann Saudi Med Review Article BACKGROUND: Human rotavirus, an important causative agent of severe gastroenteritis in infants and young children worldwide, leads to high morbidity in both developing and developed countries, including Saudi Arabia, and high mortality in developing countries. Effective control depends upon an accurate understanding of disease burden and the relative importance of circulating serotypes. METHODS: We examined the epidemiology and disease burden of rotavirus in Saudi Arabia through a review of 22 published studies of rotavirus and the aetiology of diarrhoea carried out from 1982 to 2003. RESULTS: The prevalence of rotavirus infection ranged between 10% to 46% with a median of 30%. Most cases were among children less than 2 years of age, and particularly in the first year of life. There were significant differences in seasonality within Saudi Arabia, with increased infection during winter in some cities and during summer in others. G1 was the predominant serotype followed by G4, G3 and G2, in 4 studies where strains had been G-typed. The prevalence of nontypeable strains ranged from 11.0% to 31.3%. No data were available on P types. Results of electropherotyping in 4 studies revealed that the long electropherotype was predominant. CONCLUSION: Rotavirus is an important cause of severe diarrhoea in Saudi children. However, the available data on rotavirus strains in circulation are limited and there is an urgent need for up-to-date and comprehensive studies to evaluate rotavirus strains in circulation and identify unusual types that could be incorporated into future vaccines. King Faisal Specialist Hospital and Research Centre 2006 /pmc/articles/PMC6074438/ /pubmed/16861867 http://dx.doi.org/10.5144/0256-4947.2006.184 Text en Copyright © 2006, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article
Kheyami, Ali M.
Cunliffe, Nigel A.
Hart, C. Anthony
Rotavirus infection in Saudi Arabia
title Rotavirus infection in Saudi Arabia
title_full Rotavirus infection in Saudi Arabia
title_fullStr Rotavirus infection in Saudi Arabia
title_full_unstemmed Rotavirus infection in Saudi Arabia
title_short Rotavirus infection in Saudi Arabia
title_sort rotavirus infection in saudi arabia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074438/
https://www.ncbi.nlm.nih.gov/pubmed/16861867
http://dx.doi.org/10.5144/0256-4947.2006.184
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