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Emerging Global Epidemic of Obesity: The Renal Perspective

Obesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease—a widely prevalent but often silent condition. Obesity carries...

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Autor principal: Saxena, Anil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074512/
https://www.ncbi.nlm.nih.gov/pubmed/16883080
http://dx.doi.org/10.5144/0256-4947.2006.288
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author Saxena, Anil Kumar
author_facet Saxena, Anil Kumar
author_sort Saxena, Anil Kumar
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description Obesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease—a widely prevalent but often silent condition. Obesity carries elevated risks of cardiovascular morbidity and mortality besides having an array of metabolic complications. Maladaptive glomerular hemodynamics with increased intraglomerular pressure in association with vasoactive, fibrogenic substances released from adipocytes, in addition to cytokines and hormones, are the key factors in the causation of renal injury and the progression of nephron loss among obese subjects.
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spelling pubmed-60745122018-09-21 Emerging Global Epidemic of Obesity: The Renal Perspective Saxena, Anil Kumar Ann Saudi Med Review Obesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease—a widely prevalent but often silent condition. Obesity carries elevated risks of cardiovascular morbidity and mortality besides having an array of metabolic complications. Maladaptive glomerular hemodynamics with increased intraglomerular pressure in association with vasoactive, fibrogenic substances released from adipocytes, in addition to cytokines and hormones, are the key factors in the causation of renal injury and the progression of nephron loss among obese subjects. King Faisal Specialist Hospital and Research Centre 2006 /pmc/articles/PMC6074512/ /pubmed/16883080 http://dx.doi.org/10.5144/0256-4947.2006.288 Text en Copyright © 2006, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review
Saxena, Anil Kumar
Emerging Global Epidemic of Obesity: The Renal Perspective
title Emerging Global Epidemic of Obesity: The Renal Perspective
title_full Emerging Global Epidemic of Obesity: The Renal Perspective
title_fullStr Emerging Global Epidemic of Obesity: The Renal Perspective
title_full_unstemmed Emerging Global Epidemic of Obesity: The Renal Perspective
title_short Emerging Global Epidemic of Obesity: The Renal Perspective
title_sort emerging global epidemic of obesity: the renal perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074512/
https://www.ncbi.nlm.nih.gov/pubmed/16883080
http://dx.doi.org/10.5144/0256-4947.2006.288
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