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Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism

BACKGROUND AND OBJECTIVES: Because subclinical thyroid dysfunction may be a risk factor for cardiovascular disease, we evaluated the atherosclerosis tendency in subclinical hypothyroid (SCH) patients. PATIENTS AND METHODS: Fifty-three subclinical hypothyroid patients (serum thyrotropin [TSH] concent...

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Autores principales: Turhan, Serpil, Sezer, Sevilay, Erden, Gonul, Guctekin, Ali, Ucar, Fatma, Ginis, Zeynep, Ozturk, Ozlem, Bingol, Sezin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074520/
https://www.ncbi.nlm.nih.gov/pubmed/18398274
http://dx.doi.org/10.5144/0256-4947.2008.96
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author Turhan, Serpil
Sezer, Sevilay
Erden, Gonul
Guctekin, Ali
Ucar, Fatma
Ginis, Zeynep
Ozturk, Ozlem
Bingol, Sezin
author_facet Turhan, Serpil
Sezer, Sevilay
Erden, Gonul
Guctekin, Ali
Ucar, Fatma
Ginis, Zeynep
Ozturk, Ozlem
Bingol, Sezin
author_sort Turhan, Serpil
collection PubMed
description BACKGROUND AND OBJECTIVES: Because subclinical thyroid dysfunction may be a risk factor for cardiovascular disease, we evaluated the atherosclerosis tendency in subclinical hypothyroid (SCH) patients. PATIENTS AND METHODS: Fifty-three subclinical hypothyroid patients (serum thyrotropin [TSH] concentrations >4.12 mU/L) were compared with a control group of 50 euthyroid subjects whose age, sex and body mass indices were similar to the patient group. We tested whether serum TSH concentrations were correlated with plasma total homocysteine concentration (tHcy), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG). RESULTS: There was a significant statistical difference between the patient and control groups for normal free T4 (1.02±0.17 vs. 0.86±0.13, P<.001), TSH (1.64±1.02 vs. 6.62±2.61, P<.001), TC (185±39 vs. 206±42, P=.01), TG (103±54 vs. 132±85, P=.04), LDL-C (114±33 vs. 127±36, P=.04), and TC/HDL-C (3.81±106 vs. 4.19±1.02, P=.04), respectively. No statistically significant difference was found between the two groups for HDL-C, VLDL-C, LDL-C/HDL-C, and tHcy. Serum TSH was significantly correlated with plasma tHcy (r=0.55; P=.001), TC (r=0.52; P=.001), LDL-C (r=0.49; P=.001), TC/HDL-C (r=0.38; P=.002) and LDL-C/HDL-C (r=0.36; P=.004) across all participants. CONCLUSION: Our study suggests that the atherogenicity of SCH is not mediated by hyperhomocysteinemia. Associated hyperlipidemia may explain the observed increased risk of coronary artery disease in patients with SCH.
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spelling pubmed-60745202018-09-21 Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism Turhan, Serpil Sezer, Sevilay Erden, Gonul Guctekin, Ali Ucar, Fatma Ginis, Zeynep Ozturk, Ozlem Bingol, Sezin Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: Because subclinical thyroid dysfunction may be a risk factor for cardiovascular disease, we evaluated the atherosclerosis tendency in subclinical hypothyroid (SCH) patients. PATIENTS AND METHODS: Fifty-three subclinical hypothyroid patients (serum thyrotropin [TSH] concentrations >4.12 mU/L) were compared with a control group of 50 euthyroid subjects whose age, sex and body mass indices were similar to the patient group. We tested whether serum TSH concentrations were correlated with plasma total homocysteine concentration (tHcy), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG). RESULTS: There was a significant statistical difference between the patient and control groups for normal free T4 (1.02±0.17 vs. 0.86±0.13, P<.001), TSH (1.64±1.02 vs. 6.62±2.61, P<.001), TC (185±39 vs. 206±42, P=.01), TG (103±54 vs. 132±85, P=.04), LDL-C (114±33 vs. 127±36, P=.04), and TC/HDL-C (3.81±106 vs. 4.19±1.02, P=.04), respectively. No statistically significant difference was found between the two groups for HDL-C, VLDL-C, LDL-C/HDL-C, and tHcy. Serum TSH was significantly correlated with plasma tHcy (r=0.55; P=.001), TC (r=0.52; P=.001), LDL-C (r=0.49; P=.001), TC/HDL-C (r=0.38; P=.002) and LDL-C/HDL-C (r=0.36; P=.004) across all participants. CONCLUSION: Our study suggests that the atherogenicity of SCH is not mediated by hyperhomocysteinemia. Associated hyperlipidemia may explain the observed increased risk of coronary artery disease in patients with SCH. King Faisal Specialist Hospital and Research Centre 2008 /pmc/articles/PMC6074520/ /pubmed/18398274 http://dx.doi.org/10.5144/0256-4947.2008.96 Text en Copyright © 2008, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Turhan, Serpil
Sezer, Sevilay
Erden, Gonul
Guctekin, Ali
Ucar, Fatma
Ginis, Zeynep
Ozturk, Ozlem
Bingol, Sezin
Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism
title Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism
title_full Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism
title_fullStr Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism
title_full_unstemmed Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism
title_short Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism
title_sort plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074520/
https://www.ncbi.nlm.nih.gov/pubmed/18398274
http://dx.doi.org/10.5144/0256-4947.2008.96
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