Cargando…

Sarcomatoid renal cell carcinoma with rhabdoid features

Sarcomatoid renal cell carcinoma (SRCC) with rhabdoid features is a rare tumor with aggressive behavior and poor prognosis. We report a case of a 71-year-old man with a large left-sided renal mass. Nephrectomy specimen revealed clear cell carcinoma with sarcomatoid and rhabdoid tumor cells. The rhab...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Saidi, Nagla Ahmed, Akhtar, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074894/
https://www.ncbi.nlm.nih.gov/pubmed/24188946
http://dx.doi.org/10.5144/0256-4947.2013.495
_version_ 1783344504139415552
author Al-Saidi, Nagla Ahmed
Akhtar, Mohammed
author_facet Al-Saidi, Nagla Ahmed
Akhtar, Mohammed
author_sort Al-Saidi, Nagla Ahmed
collection PubMed
description Sarcomatoid renal cell carcinoma (SRCC) with rhabdoid features is a rare tumor with aggressive behavior and poor prognosis. We report a case of a 71-year-old man with a large left-sided renal mass. Nephrectomy specimen revealed clear cell carcinoma with sarcomatoid and rhabdoid tumor cells. The rhabdoid cells were immunoreactive for mesenchymal markers such as vimentin, epithelial markers such as cytokeratin, and epithelial membrane antigen. These cells were also positive for p53 and had a high proliferation index. The rhabdoid component also demonstrated the loss of immunostaining for integrase interactor 1 (INI1), which stained the other components of the tumor. Only a few cases are available in the published reports documenting rhabdoid cells in SRCC. None of these cases were studied by INI1 immunostain.
format Online
Article
Text
id pubmed-6074894
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher King Faisal Specialist Hospital and Research Centre
record_format MEDLINE/PubMed
spelling pubmed-60748942018-09-21 Sarcomatoid renal cell carcinoma with rhabdoid features Al-Saidi, Nagla Ahmed Akhtar, Mohammed Ann Saudi Med Case Report Sarcomatoid renal cell carcinoma (SRCC) with rhabdoid features is a rare tumor with aggressive behavior and poor prognosis. We report a case of a 71-year-old man with a large left-sided renal mass. Nephrectomy specimen revealed clear cell carcinoma with sarcomatoid and rhabdoid tumor cells. The rhabdoid cells were immunoreactive for mesenchymal markers such as vimentin, epithelial markers such as cytokeratin, and epithelial membrane antigen. These cells were also positive for p53 and had a high proliferation index. The rhabdoid component also demonstrated the loss of immunostaining for integrase interactor 1 (INI1), which stained the other components of the tumor. Only a few cases are available in the published reports documenting rhabdoid cells in SRCC. None of these cases were studied by INI1 immunostain. King Faisal Specialist Hospital and Research Centre 2013 /pmc/articles/PMC6074894/ /pubmed/24188946 http://dx.doi.org/10.5144/0256-4947.2013.495 Text en Copyright © 2013, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Case Report
Al-Saidi, Nagla Ahmed
Akhtar, Mohammed
Sarcomatoid renal cell carcinoma with rhabdoid features
title Sarcomatoid renal cell carcinoma with rhabdoid features
title_full Sarcomatoid renal cell carcinoma with rhabdoid features
title_fullStr Sarcomatoid renal cell carcinoma with rhabdoid features
title_full_unstemmed Sarcomatoid renal cell carcinoma with rhabdoid features
title_short Sarcomatoid renal cell carcinoma with rhabdoid features
title_sort sarcomatoid renal cell carcinoma with rhabdoid features
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074894/
https://www.ncbi.nlm.nih.gov/pubmed/24188946
http://dx.doi.org/10.5144/0256-4947.2013.495
work_keys_str_mv AT alsaidinaglaahmed sarcomatoidrenalcellcarcinomawithrhabdoidfeatures
AT akhtarmohammed sarcomatoidrenalcellcarcinomawithrhabdoidfeatures