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DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease

The levels of copper, which is an essential element in living organisms, are under tight homeostatic control. Inactivating mutations in ATP7B, a P-type Cu-ATPase that functions in copper excretion, promote aberrant accumulation of the metal, primarily the in liver and brain. This condition underlies...

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Detalles Bibliográficos
Autores principales: Krishnan, Navasona, Felice, Christy, Rivera, Keith, Pappin, Darryl J., Tonks, Nicholas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075031/
https://www.ncbi.nlm.nih.gov/pubmed/29945887
http://dx.doi.org/10.1101/gad.314658.118