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DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease
The levels of copper, which is an essential element in living organisms, are under tight homeostatic control. Inactivating mutations in ATP7B, a P-type Cu-ATPase that functions in copper excretion, promote aberrant accumulation of the metal, primarily the in liver and brain. This condition underlies...
Autores principales: | Krishnan, Navasona, Felice, Christy, Rivera, Keith, Pappin, Darryl J., Tonks, Nicholas K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075031/ https://www.ncbi.nlm.nih.gov/pubmed/29945887 http://dx.doi.org/10.1101/gad.314658.118 |
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