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Yra1-bound RNA–DNA hybrids cause orientation-independent transcription–replication collisions and telomere instability
R loops are an important source of genome instability, largely due to their negative impact on replication progression. Yra1/ALY is an abundant RNA-binding factor conserved from yeast to humans and required for mRNA export, but its excess causes lethality and genome instability. Here, we show that,...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075034/ https://www.ncbi.nlm.nih.gov/pubmed/29954833 http://dx.doi.org/10.1101/gad.311274.117 |